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Expression of Epidermal c-Kit+ of Vitiligo Lesions Is Related to Responses to Excimer Laser
BACKGROUND: The survival and growth of melanocytes are controlled by the binding of stem cell factor to its cell surface receptor c-kit+ (CD117). We have observed that c-kit+ melanocytes existed in some lesions of vitiligo, while Melan A+ cells were absent. OBJECTIVE: To verify possible relation bet...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Dermatological Association; The Korean Society for Investigative Dermatology
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969475/ https://www.ncbi.nlm.nih.gov/pubmed/27489428 http://dx.doi.org/10.5021/ad.2016.28.4.457 |
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author | Park, Oun Jae Han, Ji Su Lee, Sang Hyung Park, Chan-Sik Won, Chong Hyun Lee, Mi Woo Choi, Jee Ho Chang, Sung Eun |
author_facet | Park, Oun Jae Han, Ji Su Lee, Sang Hyung Park, Chan-Sik Won, Chong Hyun Lee, Mi Woo Choi, Jee Ho Chang, Sung Eun |
author_sort | Park, Oun Jae |
collection | PubMed |
description | BACKGROUND: The survival and growth of melanocytes are controlled by the binding of stem cell factor to its cell surface receptor c-kit+ (CD117). We have observed that c-kit+ melanocytes existed in some lesions of vitiligo, while Melan A+ cells were absent. OBJECTIVE: To verify possible relation between c-kit+ expression and treatment response in non-segmental vitiligo lesions METHODS: Skin biopsies were done from the center of the 47 lesions from the 47 patients with non-segmental vitiligo. Expression of c-kit+ and Melan A, and amounts of melanin in the epidermis were assessed in each lesion, and treatment responses to excimer laser were evaluated. RESULTS: Thirty-five of the 47 lesions (74.5%) had c-kit+ phenotypes. There was significant difference of c-kit staining value between good responders in 3 months of excimer laser treatment (average of 24 sessions) and the others. CONCLUSION: c-Kit expression in vitiliginous epidermis may be related to better treatment responses to excimer laser. |
format | Online Article Text |
id | pubmed-4969475 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Korean Dermatological Association; The Korean Society for Investigative Dermatology |
record_format | MEDLINE/PubMed |
spelling | pubmed-49694752016-08-03 Expression of Epidermal c-Kit+ of Vitiligo Lesions Is Related to Responses to Excimer Laser Park, Oun Jae Han, Ji Su Lee, Sang Hyung Park, Chan-Sik Won, Chong Hyun Lee, Mi Woo Choi, Jee Ho Chang, Sung Eun Ann Dermatol Original Article BACKGROUND: The survival and growth of melanocytes are controlled by the binding of stem cell factor to its cell surface receptor c-kit+ (CD117). We have observed that c-kit+ melanocytes existed in some lesions of vitiligo, while Melan A+ cells were absent. OBJECTIVE: To verify possible relation between c-kit+ expression and treatment response in non-segmental vitiligo lesions METHODS: Skin biopsies were done from the center of the 47 lesions from the 47 patients with non-segmental vitiligo. Expression of c-kit+ and Melan A, and amounts of melanin in the epidermis were assessed in each lesion, and treatment responses to excimer laser were evaluated. RESULTS: Thirty-five of the 47 lesions (74.5%) had c-kit+ phenotypes. There was significant difference of c-kit staining value between good responders in 3 months of excimer laser treatment (average of 24 sessions) and the others. CONCLUSION: c-Kit expression in vitiliginous epidermis may be related to better treatment responses to excimer laser. Korean Dermatological Association; The Korean Society for Investigative Dermatology 2016-08 2016-07-26 /pmc/articles/PMC4969475/ /pubmed/27489428 http://dx.doi.org/10.5021/ad.2016.28.4.457 Text en Copyright © 2016 The Korean Dermatological Association and The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Park, Oun Jae Han, Ji Su Lee, Sang Hyung Park, Chan-Sik Won, Chong Hyun Lee, Mi Woo Choi, Jee Ho Chang, Sung Eun Expression of Epidermal c-Kit+ of Vitiligo Lesions Is Related to Responses to Excimer Laser |
title | Expression of Epidermal c-Kit+ of Vitiligo Lesions Is Related to Responses to Excimer Laser |
title_full | Expression of Epidermal c-Kit+ of Vitiligo Lesions Is Related to Responses to Excimer Laser |
title_fullStr | Expression of Epidermal c-Kit+ of Vitiligo Lesions Is Related to Responses to Excimer Laser |
title_full_unstemmed | Expression of Epidermal c-Kit+ of Vitiligo Lesions Is Related to Responses to Excimer Laser |
title_short | Expression of Epidermal c-Kit+ of Vitiligo Lesions Is Related to Responses to Excimer Laser |
title_sort | expression of epidermal c-kit+ of vitiligo lesions is related to responses to excimer laser |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969475/ https://www.ncbi.nlm.nih.gov/pubmed/27489428 http://dx.doi.org/10.5021/ad.2016.28.4.457 |
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