The aged lymphoid tissue environment fails to support naïve T cell homeostasis

Aging is associated with a gradual loss of naïve T cells and a reciprocal increase in the proportion of memory T cells. While reduced thymic output is important, age-dependent changes in factors supporting naïve T cells homeostasis may also be involved. Indeed, we noted a dramatic decrease in the ab...

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Detalles Bibliográficos
Autores principales: Becklund, Bryan R., Purton, Jared F., Ramsey, Chris, Favre, Stéphanie, Vogt, Tobias K., Martin, Christopher E., Spasova, Darina S., Sarkisyan, Gor, LeRoy, Eric, Tan, Joyce T., Wahlus, Heidi, Bondi-Boyd, Brea, Luther, Sanjiv A., Surh, Charles D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969611/
https://www.ncbi.nlm.nih.gov/pubmed/27480406
http://dx.doi.org/10.1038/srep30842

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