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Arginine Vasopressin and Copeptin in Perinatology

Arginine vasopressin (AVP) plays a major role in the homeostasis of fluid balance, vascular tonus, and the regulation of the endocrine stress response. The measurement of AVP levels is difficult due to its short half-life and laborious method of detection. Copeptin is a more stable peptide derived f...

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Autores principales: Evers, Katrina Suzanne, Wellmann, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969663/
https://www.ncbi.nlm.nih.gov/pubmed/27532032
http://dx.doi.org/10.3389/fped.2016.00075
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author Evers, Katrina Suzanne
Wellmann, Sven
author_facet Evers, Katrina Suzanne
Wellmann, Sven
author_sort Evers, Katrina Suzanne
collection PubMed
description Arginine vasopressin (AVP) plays a major role in the homeostasis of fluid balance, vascular tonus, and the regulation of the endocrine stress response. The measurement of AVP levels is difficult due to its short half-life and laborious method of detection. Copeptin is a more stable peptide derived from the same precursor molecule, is released in an equimolar ratio to AVP, and has a very similar response to osmotic, hemodynamic, and stress-related stimuli. In fact, copeptin has been propagated as surrogate marker to indirectly determine circulating AVP concentrations in various conditions. Here, we present an overview of the current knowledge on AVP and copeptin in perinatology with a particular focus on the baby’s transition from placenta to lung breathing. We performed a systematic review of the literature on fetal stress hormone levels, including norepinephrine, cortisol, AVP, and copeptin, in regard to birth stress. Finally, diagnostic and therapeutic options for copeptin measurement and AVP functions are discussed.
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spelling pubmed-49696632016-08-16 Arginine Vasopressin and Copeptin in Perinatology Evers, Katrina Suzanne Wellmann, Sven Front Pediatr Pediatrics Arginine vasopressin (AVP) plays a major role in the homeostasis of fluid balance, vascular tonus, and the regulation of the endocrine stress response. The measurement of AVP levels is difficult due to its short half-life and laborious method of detection. Copeptin is a more stable peptide derived from the same precursor molecule, is released in an equimolar ratio to AVP, and has a very similar response to osmotic, hemodynamic, and stress-related stimuli. In fact, copeptin has been propagated as surrogate marker to indirectly determine circulating AVP concentrations in various conditions. Here, we present an overview of the current knowledge on AVP and copeptin in perinatology with a particular focus on the baby’s transition from placenta to lung breathing. We performed a systematic review of the literature on fetal stress hormone levels, including norepinephrine, cortisol, AVP, and copeptin, in regard to birth stress. Finally, diagnostic and therapeutic options for copeptin measurement and AVP functions are discussed. Frontiers Media S.A. 2016-08-02 /pmc/articles/PMC4969663/ /pubmed/27532032 http://dx.doi.org/10.3389/fped.2016.00075 Text en Copyright © 2016 Evers and Wellmann. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Evers, Katrina Suzanne
Wellmann, Sven
Arginine Vasopressin and Copeptin in Perinatology
title Arginine Vasopressin and Copeptin in Perinatology
title_full Arginine Vasopressin and Copeptin in Perinatology
title_fullStr Arginine Vasopressin and Copeptin in Perinatology
title_full_unstemmed Arginine Vasopressin and Copeptin in Perinatology
title_short Arginine Vasopressin and Copeptin in Perinatology
title_sort arginine vasopressin and copeptin in perinatology
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969663/
https://www.ncbi.nlm.nih.gov/pubmed/27532032
http://dx.doi.org/10.3389/fped.2016.00075
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