Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions

Stromal cells and osteoblasts play major roles in forming and modulating the bone marrow (BM) hematopoietic microenvironment. We have reported that FGF2 compromises stromal cell support of normal hematopoiesis. Here, we examined the effects of FGF2 on the leukemia microenvironment. In vitro, FGF2 si...

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Detalles Bibliográficos
Autores principales: Sugimoto, Keiki, Miyata, Yasuhiko, Nakayama, Takayuki, Saito, Shigeki, Suzuki, Ritsuro, Hayakawa, Fumihiko, Nishiwaki, Satoshi, Mizuno, Hiroki, Takeshita, Kyosuke, Kato, Hidefumi, Ueda, Ryuzo, Takami, Akiyoshi, Naoe, Tomoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969776/
https://www.ncbi.nlm.nih.gov/pubmed/27481339
http://dx.doi.org/10.1038/srep30779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969776/
https://www.ncbi.nlm.nih.gov/pubmed/27481339
http://dx.doi.org/10.1038/srep30779

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