The α(2)δ-1 subunit remodels Ca(V)1.2 voltage sensors and allows Ca(2+) influx at physiological membrane potentials

Excitation-evoked calcium influx across cellular membranes is strictly controlled by voltage-gated calcium channels (Ca(V)), which possess four distinct voltage-sensing domains (VSDs) that direct the opening of a central pore. The energetic interactions between the VSDs and the pore are critical for...

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Detalles Bibliográficos
Autores principales: Savalli, Nicoletta, Pantazis, Antonios, Sigg, Daniel, Weiss, James N., Neely, Alan, Olcese, Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969795/
https://www.ncbi.nlm.nih.gov/pubmed/27481713
http://dx.doi.org/10.1085/jgp.201611586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969795/
https://www.ncbi.nlm.nih.gov/pubmed/27481713
http://dx.doi.org/10.1085/jgp.201611586

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