Cargando…

The α(2)δ-1 subunit remodels Ca(V)1.2 voltage sensors and allows Ca(2+) influx at physiological membrane potentials

Excitation-evoked calcium influx across cellular membranes is strictly controlled by voltage-gated calcium channels (Ca(V)), which possess four distinct voltage-sensing domains (VSDs) that direct the opening of a central pore. The energetic interactions between the VSDs and the pore are critical for...

Descripción completa

Detalles Bibliográficos
Autores principales:	Savalli, Nicoletta, Pantazis, Antonios, Sigg, Daniel, Weiss, James N., Neely, Alan, Olcese, Riccardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969795/ https://www.ncbi.nlm.nih.gov/pubmed/27481713 http://dx.doi.org/10.1085/jgp.201611586

Ejemplares similares

Modes of Operation of the BK(Ca) Channel β(2) Subunit
por: Savalli, Nicoletta, et al.
Publicado: (2007)

The distinct role of the four voltage sensors of the skeletal Ca(V)1.1 channel in voltage-dependent activation
por: Savalli, Nicoletta, et al.
Publicado: (2021)

Suppression of ventricular arrhythmias by targeting late L-type Ca(2+) current
por: Angelini, Marina, et al.
Publicado: (2021)

The RCK1 domain of the human BK(Ca) channel transduces Ca(2+) binding into structural rearrangements
por: Yusifov, Taleh, et al.
Publicado: (2010)

Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channel
por: Pantazis, Antonios, et al.
Publicado: (2010)

STIMulating Ca(2+) influx
por: LeBrasseur, Nicole
Publicado: (2006)

Neuronal input triggers Ca(2+) influx through AMPA receptors and voltage‐gated Ca(2+) channels in oligodendrocytes
por: Barron, Tara, et al.
Publicado: (2019)

Ca(2+) Influx in T Cells: How Many Ca(2+) Channels?
por: Feske, Stefan
Publicado: (2013)

SARS-CoV-2 S Protein Subunit 1 Elicits Ca(2+) Influx – Dependent Ca(2+) Signals in Pancreatic Stellate Cells and Macrophages In Situ
por: Gerasimenko, Julia V, et al.
Publicado: (2022)

Increased Ca(2+) influx through Ca(V)1.2 drives aortic valve calcification
por: Matsui, Maiko, et al.
Publicado: (2022)

Effect of Bay K 8644 (−) and the β(2a) Subunit on Ca(2+)-dependent Inactivation in α(1C) Ca(2+) Channels
por: Noceti, Francesca, et al.
Publicado: (1998)

The voltage-gated Ca(2+) channel subunit α(2)δ-4 regulates locomotor behavior and sensorimotor gating in mice
por: Klomp, Annette, et al.
Publicado: (2022)

Orchestrating Ca(2+) influx through Ca(V)1.2 and Ca(V)3.x channels in human cerebral arteries
por: Collier, Daniel M., et al.
Publicado: (2015)

Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca(2+) release and Ca(2+) influx
por: Kilpatrick, Bethan S., et al.
Publicado: (2016)

Purinergic-mediated Ca(2+) influx in Dictyostelium discoideum
por: Ludlow, Melanie J., et al.
Publicado: (2008)

Inhibiting the Ca(2+) Influx Induced by Human CSF
por: Drews, Anna, et al.
Publicado: (2017)

Aldosterone-Induced Sarco/Endoplasmic Reticulum Ca(2+) Pump Upregulation Counterbalances Ca(v)1.2-Mediated Ca(2+) Influx in Mesenteric Arteries
por: Salazar-Enciso, Rogelio, et al.
Publicado: (2022)

Developmental Axon Degeneration Requires TRPV1-Dependent Ca(2+) Influx
por: Johnstone, Aaron D., et al.
Publicado: (2019)

Sympathetic Stimulation Upregulates the Ca(2+) Channel Subunit, Ca(V)α2δ1, via the β1 and ERK 1/2 Pathway in Neonatal Ventricular Cardiomyocytes
por: Al Katat, Aya, et al.
Publicado: (2022)

Impaired Fear Extinction Due to a Deficit in Ca(2+) Influx Through L-Type Voltage-Gated Ca(2+) Channels in Mice Deficient for Tenascin-C
por: Morellini, Fabio, et al.
Publicado: (2017)

Targeting the late component of the cardiac L-type Ca(2+) current to suppress early afterdepolarizations
por: Madhvani, Roshni V., et al.
Publicado: (2015)

Ca2+ influx activated by low pH in Chlamydomonas
Publicado: (1996)

Astrocyte Ca(2+) Influx Negatively Regulates Neuronal Activity
por: Zhang, Yao V., et al.
Publicado: (2017)

Blockage of Store-Operated Ca(2+) Influx by Synta66 is Mediated by Direct Inhibition of the Ca(2+) Selective Orai1 Pore
por: Waldherr, Linda, et al.
Publicado: (2020)

Reduced Loading of Intracellular Ca(2+) Stores and Downregulation of Capacitative Ca(2+)Influx in Bcl-2–Overexpressing Cells
por: Pinton, Paolo, et al.
Publicado: (2000)

Remodeling of ER–plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca(2+) influx in mitosis
por: Yu, Fang, et al.
Publicado: (2019)

The TRPV2 channel mediates Ca2+ influx and the Δ9-THC-dependent decrease in osmotic fragility in red blood cells
por: Belkacemi, Anouar, et al.
Publicado: (2021)

Role of the Ca(2+) channel α(2)δ-1 auxiliary subunit in proliferation and migration of human glioblastoma cells
por: Fernández-Gallardo, Miriam, et al.
Publicado: (2022)

Deletion of the Ca(2+) Channel Subunit α(2)δ3 Differentially Affects Ca(v)2.1 and Ca(v)2.2 Currents in Cultured Spiral Ganglion Neurons Before and After the Onset of Hearing
por: Stephani, Friederike, et al.
Publicado: (2019)

A Single Amino Acid Deletion (ΔF1502) in the S6 Segment of Ca(V)2.1 Domain III Associated with Congenital Ataxia Increases Channel Activity and Promotes Ca(2+) Influx
por: Bahamonde, Maria Isabel, et al.
Publicado: (2015)

Measuring the Influence of the BK(Ca) β1 Subunit on Ca(2+) Binding to the BK(Ca) Channel
por: Sweet, Tara-Beth, et al.
Publicado: (2009)

Graded Ca(2+)/calmodulin-dependent coupling of voltage-gated Ca(V)1.2 channels
por: Dixon, Rose E, et al.
Publicado: (2015)

Channelopathies in Ca(v)1.1, Ca(v)1.3, and Ca(v)1.4 voltage-gated L-type Ca(2+) channels
por: Striessnig, Jörg, et al.
Publicado: (2010)

The contractile vacuole in Ca(2+)-regulation in Dictyostelium: its essential function for cAMP-induced Ca(2+)-influx
por: Malchow, Dieter, et al.
Publicado: (2006)

Ca(2+) influx–independent synaptic potentiation mediated by mitochondrial Na(+)-Ca(2+) exchanger and protein kinase C
por: Yang, Feng, et al.
Publicado: (2003)

Na(+)-induced Ca(2+) influx through reverse mode of Na(+)-Ca(2+) exchanger in mouse ventricular cardiomyocyte
por: Yan, Zhen-Yu, et al.
Publicado: (2015)

Ca(2+) influx and the store-operated Ca(2+) entry pathway undergo regulation during mouse oocyte maturation
por: Cheon, Banyoon, et al.
Publicado: (2013)

Safranal Induces Vasorelaxation by Inhibiting Ca(2+) Influx and Na(+)/Ca(2+) Exchanger in Isolated Rat Aortic Rings
por: Al-Saigh, Noor Nadhim, et al.
Publicado: (2022)

Negatively charged residues in the first extracellular loop of the L-type Ca(V)1.2 channel anchor the interaction with the Ca(V)α2δ1 auxiliary subunit
por: Bourdin, Benoîte, et al.
Publicado: (2017)

Genetic dissection of light-induced Ca2+ influx into Drosophila photoreceptors
Publicado: (1994)

Cannot write session to /tmp/vufind_sessions/sess_vqd7kkrotfbj37l70tb8qhmu67