Insights into the structure and function of H(V)1 from a meta-analysis of mutation studies

The voltage-gated proton channel (H(V)1) is a widely distributed, proton-specific ion channel with unique properties. Since 2006, when genes for H(V)1 were identified, a vast array of mutations have been generated and characterized. Accessing this potentially useful resource is hindered, however, by the sheer number of mutations and interspecies differences in amino acid numbering. This review organizes all existing information in a logical manner to allow swift identification of studies that have characterized any particular mutation. Although much can be gained from this meta-analysis, important questions about the inner workings of H(V)1 await future revelation.