Herpetic tracheitis in association with rituximab therapy

A 58‐year old lady under active follow‐up with the respiratory services at our institution for bronchiectasis secondary to hypogammaglobulinaemia presented with hoarseness and haemoptysis. She was also receiving rituximab maintenance therapy for follicular lymphoma. Bronchoscopy demonstrated vesicul...

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Detalles Bibliográficos
Autores principales: Thong, Lorraine, Plant, Barry J, McCarthy, Julie, Murphy, Desmond M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969845/
https://www.ncbi.nlm.nih.gov/pubmed/27512561
http://dx.doi.org/10.1002/rcr2.158
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author Thong, Lorraine
Plant, Barry J
McCarthy, Julie
Murphy, Desmond M
author_facet Thong, Lorraine
Plant, Barry J
McCarthy, Julie
Murphy, Desmond M
author_sort Thong, Lorraine
collection PubMed
description A 58‐year old lady under active follow‐up with the respiratory services at our institution for bronchiectasis secondary to hypogammaglobulinaemia presented with hoarseness and haemoptysis. She was also receiving rituximab maintenance therapy for follicular lymphoma. Bronchoscopy demonstrated vesicular lesions on her vocal cords and trachea, confirmed as herpes simplex virus (HSV) on cytological analysis of brushings. She responded well to intravenous valacyclovir. Rituximab is increasingly utilised in the treatment of haematological and auto‐immune disorders. This case highlights the potential of this drug to potentiate susceptibility to infection in an already immunocompromised individual.
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spelling pubmed-49698452016-08-11 Herpetic tracheitis in association with rituximab therapy Thong, Lorraine Plant, Barry J McCarthy, Julie Murphy, Desmond M Respirol Case Rep Case Reports A 58‐year old lady under active follow‐up with the respiratory services at our institution for bronchiectasis secondary to hypogammaglobulinaemia presented with hoarseness and haemoptysis. She was also receiving rituximab maintenance therapy for follicular lymphoma. Bronchoscopy demonstrated vesicular lesions on her vocal cords and trachea, confirmed as herpes simplex virus (HSV) on cytological analysis of brushings. She responded well to intravenous valacyclovir. Rituximab is increasingly utilised in the treatment of haematological and auto‐immune disorders. This case highlights the potential of this drug to potentiate susceptibility to infection in an already immunocompromised individual. John Wiley and Sons Inc. 2016-05-05 /pmc/articles/PMC4969845/ /pubmed/27512561 http://dx.doi.org/10.1002/rcr2.158 Text en © 2016 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Thong, Lorraine
Plant, Barry J
McCarthy, Julie
Murphy, Desmond M
Herpetic tracheitis in association with rituximab therapy
title Herpetic tracheitis in association with rituximab therapy
title_full Herpetic tracheitis in association with rituximab therapy
title_fullStr Herpetic tracheitis in association with rituximab therapy
title_full_unstemmed Herpetic tracheitis in association with rituximab therapy
title_short Herpetic tracheitis in association with rituximab therapy
title_sort herpetic tracheitis in association with rituximab therapy
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969845/
https://www.ncbi.nlm.nih.gov/pubmed/27512561
http://dx.doi.org/10.1002/rcr2.158
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