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Multicentric Castleman's disease developing during follow‐up of sarcoidosis

Pulmonary sarcoidosis is reported to have complication of lymphoproliferative disease such as malignant lymphoma, but the complication of multicentric Castleman's disease (MCD) is rarely reported. In our case of a 60‐year‐old woman, bilateral hilar lymphadenopathy was noted in her chest X‐ray....

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Autores principales: Sawata, Tetsuro, Bando, Masashi, Nakayama, Masayuki, Mato, Naoko, Takemura, Tamiko, Sugiyama, Yukihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969854/
https://www.ncbi.nlm.nih.gov/pubmed/27512568
http://dx.doi.org/10.1002/rcr2.168
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author Sawata, Tetsuro
Bando, Masashi
Nakayama, Masayuki
Mato, Naoko
Takemura, Tamiko
Sugiyama, Yukihiko
author_facet Sawata, Tetsuro
Bando, Masashi
Nakayama, Masayuki
Mato, Naoko
Takemura, Tamiko
Sugiyama, Yukihiko
author_sort Sawata, Tetsuro
collection PubMed
description Pulmonary sarcoidosis is reported to have complication of lymphoproliferative disease such as malignant lymphoma, but the complication of multicentric Castleman's disease (MCD) is rarely reported. In our case of a 60‐year‐old woman, bilateral hilar lymphadenopathy was noted in her chest X‐ray. We performed a transbronchial lung biopsy. She was diagnosed as having pulmonary sarcoidosis (Stage II). The shadow on chest X‐ray disappeared without treatment. However, after 8 years, swelling of the mediastinal and abdominal lymph node, thickened bronchovascular bundle, and multiple nodular shadows were identified, and a thoracoscopic lung biopsy was performed. Based on the histopathological findings and elevated serum interleukin‐6 level (75.7 pg/mL), she was diagnosed with pulmonary sarcoidosis complicated by MCD. When a change in chest X‐ray findings are found during monitoring of pulmonary sarcoidosis, it is important to proceed with a thoracoscopic lung biopsy, because of the possibility of the rare complication of MCD.
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spelling pubmed-49698542016-08-11 Multicentric Castleman's disease developing during follow‐up of sarcoidosis Sawata, Tetsuro Bando, Masashi Nakayama, Masayuki Mato, Naoko Takemura, Tamiko Sugiyama, Yukihiko Respirol Case Rep Case Reports Pulmonary sarcoidosis is reported to have complication of lymphoproliferative disease such as malignant lymphoma, but the complication of multicentric Castleman's disease (MCD) is rarely reported. In our case of a 60‐year‐old woman, bilateral hilar lymphadenopathy was noted in her chest X‐ray. We performed a transbronchial lung biopsy. She was diagnosed as having pulmonary sarcoidosis (Stage II). The shadow on chest X‐ray disappeared without treatment. However, after 8 years, swelling of the mediastinal and abdominal lymph node, thickened bronchovascular bundle, and multiple nodular shadows were identified, and a thoracoscopic lung biopsy was performed. Based on the histopathological findings and elevated serum interleukin‐6 level (75.7 pg/mL), she was diagnosed with pulmonary sarcoidosis complicated by MCD. When a change in chest X‐ray findings are found during monitoring of pulmonary sarcoidosis, it is important to proceed with a thoracoscopic lung biopsy, because of the possibility of the rare complication of MCD. John Wiley and Sons Inc. 2016-05-28 /pmc/articles/PMC4969854/ /pubmed/27512568 http://dx.doi.org/10.1002/rcr2.168 Text en © 2016 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Sawata, Tetsuro
Bando, Masashi
Nakayama, Masayuki
Mato, Naoko
Takemura, Tamiko
Sugiyama, Yukihiko
Multicentric Castleman's disease developing during follow‐up of sarcoidosis
title Multicentric Castleman's disease developing during follow‐up of sarcoidosis
title_full Multicentric Castleman's disease developing during follow‐up of sarcoidosis
title_fullStr Multicentric Castleman's disease developing during follow‐up of sarcoidosis
title_full_unstemmed Multicentric Castleman's disease developing during follow‐up of sarcoidosis
title_short Multicentric Castleman's disease developing during follow‐up of sarcoidosis
title_sort multicentric castleman's disease developing during follow‐up of sarcoidosis
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969854/
https://www.ncbi.nlm.nih.gov/pubmed/27512568
http://dx.doi.org/10.1002/rcr2.168
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