Apolipoprotein A-I gene transfer exerts immunomodulatory effects and reduces vascular inflammation and fibrosis in ob/ob mice

BACKGROUND: Obesity is associated with vascular inflammation, fibrosis and reduced high-density lipoproteins (HDL)-cholesterol. We aimed to investigate whether adenoviral gene transfer with human apolipoprotein (apo) A-I (Ad.A-I), the main apo of HDL, could exert immunomodulatory effects and counter...

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Autores principales: Spillmann, Frank, De Geest, Bart, Muthuramu, Ilayaraja, Amin, Ruhul, Miteva, Kapka, Pieske, Burkert, Tschöpe, Carsten, Van Linthout, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969975/
https://www.ncbi.nlm.nih.gov/pubmed/27486384
http://dx.doi.org/10.1186/s12950-016-0131-6

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