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The fibronectin III-1 domain activates a PI3-Kinase/Akt signaling pathway leading to αvβ5 integrin activation and TRAIL resistance in human lung cancer cells

BACKGROUND: Fibronectin is a mechanically sensitive protein which is organized in the extracellular matrix as a network of interacting fibrils. The lung tumor stroma is enriched for fibronectin which is thought to contribute to metastasis and drug resistance. Fibronectin is an elastic, multi-modular...

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Detalles Bibliográficos
Autores principales:	Cho, Christina, Horzempa, Carol, Jones, David, McKeown-Longo, Paula J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970220/ https://www.ncbi.nlm.nih.gov/pubmed/27484721 http://dx.doi.org/10.1186/s12885-016-2621-6

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