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Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease
BACKGROUND: Little is known about the patterns of brain atrophy in prodromal dementia with Lewy bodies (pro-DLB). METHODS: In this study, we used SPM8 with diffeomorphic anatomical registration through exponentiated lie algebra to measure grey matter (GM) volume and investigate patterns of GM atroph...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970221/ https://www.ncbi.nlm.nih.gov/pubmed/27484179 http://dx.doi.org/10.1186/s13195-016-0198-6 |
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author | Blanc, Frederic Colloby, Sean J. Cretin, Benjamin de Sousa, Paulo Loureiro Demuynck, Catherine O’Brien, John T. Martin-Hunyadi, Catherine McKeith, Ian Philippi, Nathalie Taylor, John-Paul |
author_facet | Blanc, Frederic Colloby, Sean J. Cretin, Benjamin de Sousa, Paulo Loureiro Demuynck, Catherine O’Brien, John T. Martin-Hunyadi, Catherine McKeith, Ian Philippi, Nathalie Taylor, John-Paul |
author_sort | Blanc, Frederic |
collection | PubMed |
description | BACKGROUND: Little is known about the patterns of brain atrophy in prodromal dementia with Lewy bodies (pro-DLB). METHODS: In this study, we used SPM8 with diffeomorphic anatomical registration through exponentiated lie algebra to measure grey matter (GM) volume and investigate patterns of GM atrophy in pro-DLB (n = 28) and prodromal Alzheimer’s disease (pro-AD) (n = 27) and compared and contrasted them with those in elderly control subjects (n = 33) (P ≤ 0.05 corrected for family-wise error). RESULTS: Patients with pro-DLB showed diminished GM volumes of bilateral insulae and right anterior cingulate cortex compared with control subjects. Comparison of GM volume between patients with pro-AD and control subjects showed a more extensive pattern, with volume reductions in temporal (hippocampi and superior and middle gyri), parietal and frontal structures in the former. Direct comparison of prodromal groups suggested that more atrophy was evident in the parietal lobes of patients with pro-AD than patients with pro-DLB. In patients with pro-DLB, we found that visual hallucinations were associated with relative atrophy of the left cuneus. CONCLUSIONS: Atrophy in pro-DLB involves the insulae and anterior cingulate cortex, regions rich in von Economo neurons, which we speculate may contribute to the early clinical phenotype of pro-DLB. |
format | Online Article Text |
id | pubmed-4970221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-49702212016-08-03 Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease Blanc, Frederic Colloby, Sean J. Cretin, Benjamin de Sousa, Paulo Loureiro Demuynck, Catherine O’Brien, John T. Martin-Hunyadi, Catherine McKeith, Ian Philippi, Nathalie Taylor, John-Paul Alzheimers Res Ther Research BACKGROUND: Little is known about the patterns of brain atrophy in prodromal dementia with Lewy bodies (pro-DLB). METHODS: In this study, we used SPM8 with diffeomorphic anatomical registration through exponentiated lie algebra to measure grey matter (GM) volume and investigate patterns of GM atrophy in pro-DLB (n = 28) and prodromal Alzheimer’s disease (pro-AD) (n = 27) and compared and contrasted them with those in elderly control subjects (n = 33) (P ≤ 0.05 corrected for family-wise error). RESULTS: Patients with pro-DLB showed diminished GM volumes of bilateral insulae and right anterior cingulate cortex compared with control subjects. Comparison of GM volume between patients with pro-AD and control subjects showed a more extensive pattern, with volume reductions in temporal (hippocampi and superior and middle gyri), parietal and frontal structures in the former. Direct comparison of prodromal groups suggested that more atrophy was evident in the parietal lobes of patients with pro-AD than patients with pro-DLB. In patients with pro-DLB, we found that visual hallucinations were associated with relative atrophy of the left cuneus. CONCLUSIONS: Atrophy in pro-DLB involves the insulae and anterior cingulate cortex, regions rich in von Economo neurons, which we speculate may contribute to the early clinical phenotype of pro-DLB. BioMed Central 2016-07-20 /pmc/articles/PMC4970221/ /pubmed/27484179 http://dx.doi.org/10.1186/s13195-016-0198-6 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Blanc, Frederic Colloby, Sean J. Cretin, Benjamin de Sousa, Paulo Loureiro Demuynck, Catherine O’Brien, John T. Martin-Hunyadi, Catherine McKeith, Ian Philippi, Nathalie Taylor, John-Paul Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease |
title | Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease |
title_full | Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease |
title_fullStr | Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease |
title_full_unstemmed | Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease |
title_short | Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease |
title_sort | grey matter atrophy in prodromal stage of dementia with lewy bodies and alzheimer’s disease |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970221/ https://www.ncbi.nlm.nih.gov/pubmed/27484179 http://dx.doi.org/10.1186/s13195-016-0198-6 |
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