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Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease

BACKGROUND: Little is known about the patterns of brain atrophy in prodromal dementia with Lewy bodies (pro-DLB). METHODS: In this study, we used SPM8 with diffeomorphic anatomical registration through exponentiated lie algebra to measure grey matter (GM) volume and investigate patterns of GM atroph...

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Autores principales: Blanc, Frederic, Colloby, Sean J., Cretin, Benjamin, de Sousa, Paulo Loureiro, Demuynck, Catherine, O’Brien, John T., Martin-Hunyadi, Catherine, McKeith, Ian, Philippi, Nathalie, Taylor, John-Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970221/
https://www.ncbi.nlm.nih.gov/pubmed/27484179
http://dx.doi.org/10.1186/s13195-016-0198-6
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author Blanc, Frederic
Colloby, Sean J.
Cretin, Benjamin
de Sousa, Paulo Loureiro
Demuynck, Catherine
O’Brien, John T.
Martin-Hunyadi, Catherine
McKeith, Ian
Philippi, Nathalie
Taylor, John-Paul
author_facet Blanc, Frederic
Colloby, Sean J.
Cretin, Benjamin
de Sousa, Paulo Loureiro
Demuynck, Catherine
O’Brien, John T.
Martin-Hunyadi, Catherine
McKeith, Ian
Philippi, Nathalie
Taylor, John-Paul
author_sort Blanc, Frederic
collection PubMed
description BACKGROUND: Little is known about the patterns of brain atrophy in prodromal dementia with Lewy bodies (pro-DLB). METHODS: In this study, we used SPM8 with diffeomorphic anatomical registration through exponentiated lie algebra to measure grey matter (GM) volume and investigate patterns of GM atrophy in pro-DLB (n = 28) and prodromal Alzheimer’s disease (pro-AD) (n = 27) and compared and contrasted them with those in elderly control subjects (n = 33) (P ≤ 0.05 corrected for family-wise error). RESULTS: Patients with pro-DLB showed diminished GM volumes of bilateral insulae and right anterior cingulate cortex compared with control subjects. Comparison of GM volume between patients with pro-AD and control subjects showed a more extensive pattern, with volume reductions in temporal (hippocampi and superior and middle gyri), parietal and frontal structures in the former. Direct comparison of prodromal groups suggested that more atrophy was evident in the parietal lobes of patients with pro-AD than patients with pro-DLB. In patients with pro-DLB, we found that visual hallucinations were associated with relative atrophy of the left cuneus. CONCLUSIONS: Atrophy in pro-DLB involves the insulae and anterior cingulate cortex, regions rich in von Economo neurons, which we speculate may contribute to the early clinical phenotype of pro-DLB.
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spelling pubmed-49702212016-08-03 Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease Blanc, Frederic Colloby, Sean J. Cretin, Benjamin de Sousa, Paulo Loureiro Demuynck, Catherine O’Brien, John T. Martin-Hunyadi, Catherine McKeith, Ian Philippi, Nathalie Taylor, John-Paul Alzheimers Res Ther Research BACKGROUND: Little is known about the patterns of brain atrophy in prodromal dementia with Lewy bodies (pro-DLB). METHODS: In this study, we used SPM8 with diffeomorphic anatomical registration through exponentiated lie algebra to measure grey matter (GM) volume and investigate patterns of GM atrophy in pro-DLB (n = 28) and prodromal Alzheimer’s disease (pro-AD) (n = 27) and compared and contrasted them with those in elderly control subjects (n = 33) (P ≤ 0.05 corrected for family-wise error). RESULTS: Patients with pro-DLB showed diminished GM volumes of bilateral insulae and right anterior cingulate cortex compared with control subjects. Comparison of GM volume between patients with pro-AD and control subjects showed a more extensive pattern, with volume reductions in temporal (hippocampi and superior and middle gyri), parietal and frontal structures in the former. Direct comparison of prodromal groups suggested that more atrophy was evident in the parietal lobes of patients with pro-AD than patients with pro-DLB. In patients with pro-DLB, we found that visual hallucinations were associated with relative atrophy of the left cuneus. CONCLUSIONS: Atrophy in pro-DLB involves the insulae and anterior cingulate cortex, regions rich in von Economo neurons, which we speculate may contribute to the early clinical phenotype of pro-DLB. BioMed Central 2016-07-20 /pmc/articles/PMC4970221/ /pubmed/27484179 http://dx.doi.org/10.1186/s13195-016-0198-6 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Blanc, Frederic
Colloby, Sean J.
Cretin, Benjamin
de Sousa, Paulo Loureiro
Demuynck, Catherine
O’Brien, John T.
Martin-Hunyadi, Catherine
McKeith, Ian
Philippi, Nathalie
Taylor, John-Paul
Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease
title Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease
title_full Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease
title_fullStr Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease
title_full_unstemmed Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease
title_short Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease
title_sort grey matter atrophy in prodromal stage of dementia with lewy bodies and alzheimer’s disease
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970221/
https://www.ncbi.nlm.nih.gov/pubmed/27484179
http://dx.doi.org/10.1186/s13195-016-0198-6
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