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REM sleep behavior disorder was associated with Parkinson’s disease: a community-based study
BACKGROUND: Our study was aimed to validate a modified RBD (REM sleep behavior disorder) single question (RBD1Q-C), study the prevalence of probable RBD (pRBD) in a rural community based on RBD1Q-C and investigate the association between pRBD and Parkinson’s disease (PD). METHODS: The validation stu...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970245/ https://www.ncbi.nlm.nih.gov/pubmed/27484952 http://dx.doi.org/10.1186/s12883-016-0640-1 |
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author | Ma, Jian-Fang Hou, Miao-Miao Tang, Hui-Dong Gao, Xiang Liang, Liang Zhu, Li-Fang Zhou, Yi Zha, Sheng-Yu Cui, Shi-Shuang Du, Juan-Juan Li, Gen Liu, Jun Chen, Sheng-Di |
author_facet | Ma, Jian-Fang Hou, Miao-Miao Tang, Hui-Dong Gao, Xiang Liang, Liang Zhu, Li-Fang Zhou, Yi Zha, Sheng-Yu Cui, Shi-Shuang Du, Juan-Juan Li, Gen Liu, Jun Chen, Sheng-Di |
author_sort | Ma, Jian-Fang |
collection | PubMed |
description | BACKGROUND: Our study was aimed to validate a modified RBD (REM sleep behavior disorder) single question (RBD1Q-C), study the prevalence of probable RBD (pRBD) in a rural community based on RBD1Q-C and investigate the association between pRBD and Parkinson’s disease (PD). METHODS: The validation study of RBD1Q-C included 32 Chinese participants (14 idiopathic RBD patients and 18 controls). All participants underwent a polysomnogram (PSG). We then conducted a door-to-door survey to estimate the prevalence of pRBD assessed by RBD1Q-C, and its association with PD among 19614 residents who lived in Malu community of Shanghai, China. RESULTS: RBD1Q-C demonstrated a high sensitivity of 100 %, a moderate specificity of 55.6 %. The agreement between RBD1Q-C and PSG-based RBD diagnosis was good (k = 0.552). PPV of the RBD1Q-C was 63.6 % and NPV was 100 %. The prevalence of pRBD in Malu community was 4.9 %. In people over 50 years old, presence of pRBD was significantly associated with increased risk of having PD (odds ratio = 2.61, 95 % CI: 1.56–4.39). CONCLUSION: RBD1Q-C was shown to be a useful screening tool. Based on the RBD1Q-C, we found that pRBD was not rare in Chinese rural population and associated with odds of PD, calling for more attention from patients, caregivers and physicians. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12883-016-0640-1) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4970245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-49702452016-08-03 REM sleep behavior disorder was associated with Parkinson’s disease: a community-based study Ma, Jian-Fang Hou, Miao-Miao Tang, Hui-Dong Gao, Xiang Liang, Liang Zhu, Li-Fang Zhou, Yi Zha, Sheng-Yu Cui, Shi-Shuang Du, Juan-Juan Li, Gen Liu, Jun Chen, Sheng-Di BMC Neurol Research Article BACKGROUND: Our study was aimed to validate a modified RBD (REM sleep behavior disorder) single question (RBD1Q-C), study the prevalence of probable RBD (pRBD) in a rural community based on RBD1Q-C and investigate the association between pRBD and Parkinson’s disease (PD). METHODS: The validation study of RBD1Q-C included 32 Chinese participants (14 idiopathic RBD patients and 18 controls). All participants underwent a polysomnogram (PSG). We then conducted a door-to-door survey to estimate the prevalence of pRBD assessed by RBD1Q-C, and its association with PD among 19614 residents who lived in Malu community of Shanghai, China. RESULTS: RBD1Q-C demonstrated a high sensitivity of 100 %, a moderate specificity of 55.6 %. The agreement between RBD1Q-C and PSG-based RBD diagnosis was good (k = 0.552). PPV of the RBD1Q-C was 63.6 % and NPV was 100 %. The prevalence of pRBD in Malu community was 4.9 %. In people over 50 years old, presence of pRBD was significantly associated with increased risk of having PD (odds ratio = 2.61, 95 % CI: 1.56–4.39). CONCLUSION: RBD1Q-C was shown to be a useful screening tool. Based on the RBD1Q-C, we found that pRBD was not rare in Chinese rural population and associated with odds of PD, calling for more attention from patients, caregivers and physicians. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12883-016-0640-1) contains supplementary material, which is available to authorized users. BioMed Central 2016-08-02 /pmc/articles/PMC4970245/ /pubmed/27484952 http://dx.doi.org/10.1186/s12883-016-0640-1 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Ma, Jian-Fang Hou, Miao-Miao Tang, Hui-Dong Gao, Xiang Liang, Liang Zhu, Li-Fang Zhou, Yi Zha, Sheng-Yu Cui, Shi-Shuang Du, Juan-Juan Li, Gen Liu, Jun Chen, Sheng-Di REM sleep behavior disorder was associated with Parkinson’s disease: a community-based study |
title | REM sleep behavior disorder was associated with Parkinson’s disease: a community-based study |
title_full | REM sleep behavior disorder was associated with Parkinson’s disease: a community-based study |
title_fullStr | REM sleep behavior disorder was associated with Parkinson’s disease: a community-based study |
title_full_unstemmed | REM sleep behavior disorder was associated with Parkinson’s disease: a community-based study |
title_short | REM sleep behavior disorder was associated with Parkinson’s disease: a community-based study |
title_sort | rem sleep behavior disorder was associated with parkinson’s disease: a community-based study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970245/ https://www.ncbi.nlm.nih.gov/pubmed/27484952 http://dx.doi.org/10.1186/s12883-016-0640-1 |
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