A mitochondrial-derived vesicle HOPS to endolysosomes using Syntaxin-17

Damaged mitochondrial content is packaged in mitochondrial-derived vesicles (MDVs), which are targeted for degradation through an unclear mechanism. McLelland et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603105) show that the SNARE Syntaxin-17 mediates MDV fusion with endolysosomes,...

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Detalles Bibliográficos
Autor principal: Juhász, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970333/
https://www.ncbi.nlm.nih.gov/pubmed/27458131
http://dx.doi.org/10.1083/jcb.201607024
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author Juhász, Gábor
author_facet Juhász, Gábor
author_sort Juhász, Gábor
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description Damaged mitochondrial content is packaged in mitochondrial-derived vesicles (MDVs), which are targeted for degradation through an unclear mechanism. McLelland et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603105) show that the SNARE Syntaxin-17 mediates MDV fusion with endolysosomes, promoting the delivery of mitochondrial cargo to lysosomes for degradation.
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spelling pubmed-49703332017-02-01 A mitochondrial-derived vesicle HOPS to endolysosomes using Syntaxin-17 Juhász, Gábor J Cell Biol Commentary Damaged mitochondrial content is packaged in mitochondrial-derived vesicles (MDVs), which are targeted for degradation through an unclear mechanism. McLelland et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603105) show that the SNARE Syntaxin-17 mediates MDV fusion with endolysosomes, promoting the delivery of mitochondrial cargo to lysosomes for degradation. The Rockefeller University Press 2016-08-01 /pmc/articles/PMC4970333/ /pubmed/27458131 http://dx.doi.org/10.1083/jcb.201607024 Text en © 2016 Juhász This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
Juhász, Gábor
A mitochondrial-derived vesicle HOPS to endolysosomes using Syntaxin-17
title A mitochondrial-derived vesicle HOPS to endolysosomes using Syntaxin-17
title_full A mitochondrial-derived vesicle HOPS to endolysosomes using Syntaxin-17
title_fullStr A mitochondrial-derived vesicle HOPS to endolysosomes using Syntaxin-17
title_full_unstemmed A mitochondrial-derived vesicle HOPS to endolysosomes using Syntaxin-17
title_short A mitochondrial-derived vesicle HOPS to endolysosomes using Syntaxin-17
title_sort mitochondrial-derived vesicle hops to endolysosomes using syntaxin-17
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970333/
https://www.ncbi.nlm.nih.gov/pubmed/27458131
http://dx.doi.org/10.1083/jcb.201607024
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