Cargando…

Serum cortisol level and adrenal reserve as a predictor of patients’ outcome after successful cardiopulmonary resuscitation

Introduction: It is thought that pituitary-adrenal axis has a fundamental role in outcome of cardiopulmonary arrest (CPA). This study designed to evaluate the correlation between adrenal reserve and post-resuscitation outcome. Methods: In this clinical trial study, 52 consecutive patients with CPA w...

Descripción completa

Detalles Bibliográficos
Autores principales: Mosaddegh, Reza, Kianmehr, Nahid, Mahshidfar, Babak, Rahmani, Zahra, Aghdam, Hamed, Mofidi, Mani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970572/
https://www.ncbi.nlm.nih.gov/pubmed/27489598
http://dx.doi.org/10.15171/jcvtr.2016.12
_version_ 1782445989721800704
author Mosaddegh, Reza
Kianmehr, Nahid
Mahshidfar, Babak
Rahmani, Zahra
Aghdam, Hamed
Mofidi, Mani
author_facet Mosaddegh, Reza
Kianmehr, Nahid
Mahshidfar, Babak
Rahmani, Zahra
Aghdam, Hamed
Mofidi, Mani
author_sort Mosaddegh, Reza
collection PubMed
description Introduction: It is thought that pituitary-adrenal axis has a fundamental role in outcome of cardiopulmonary arrest (CPA). This study designed to evaluate the correlation between adrenal reserve and post-resuscitation outcome. Methods: In this clinical trial study, 52 consecutive patients with CPA were enrolled in two emergency departments (EDs) over a 3-month period. Plasma cortisol level was measured at the beginning of CPR. Intravenous adrenocorticotropic hormone (ACTH) stimulation test was carried out after successful CPR, and blood samples were taken at 30 and 60 minutes, and 24 hours thereafter. Patients were divided into two groups: in-hospital death or hospital discharge. Results: In patients who died, baseline and post-ACTH serum cortisol after 30 and 60 minutes and 24 hours were higher than patients who discharged from the hospital, but it was not statistically significant except to that of minute 60 (P=0.49). A model of multivariate logistic regression analysis showed that age and need for vasopressor infusion correlated with mortality. Conclusion: Current study could not show the statistically significant difference in initial and post-ACTH serum cortisol levels between survivor and non-survivor patients with cardiac arrest who had initial successful CPR, except to that of minute 60.
format Online
Article
Text
id pubmed-4970572
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Tabriz University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-49705722016-08-03 Serum cortisol level and adrenal reserve as a predictor of patients’ outcome after successful cardiopulmonary resuscitation Mosaddegh, Reza Kianmehr, Nahid Mahshidfar, Babak Rahmani, Zahra Aghdam, Hamed Mofidi, Mani J Cardiovasc Thorac Res Original Article Introduction: It is thought that pituitary-adrenal axis has a fundamental role in outcome of cardiopulmonary arrest (CPA). This study designed to evaluate the correlation between adrenal reserve and post-resuscitation outcome. Methods: In this clinical trial study, 52 consecutive patients with CPA were enrolled in two emergency departments (EDs) over a 3-month period. Plasma cortisol level was measured at the beginning of CPR. Intravenous adrenocorticotropic hormone (ACTH) stimulation test was carried out after successful CPR, and blood samples were taken at 30 and 60 minutes, and 24 hours thereafter. Patients were divided into two groups: in-hospital death or hospital discharge. Results: In patients who died, baseline and post-ACTH serum cortisol after 30 and 60 minutes and 24 hours were higher than patients who discharged from the hospital, but it was not statistically significant except to that of minute 60 (P=0.49). A model of multivariate logistic regression analysis showed that age and need for vasopressor infusion correlated with mortality. Conclusion: Current study could not show the statistically significant difference in initial and post-ACTH serum cortisol levels between survivor and non-survivor patients with cardiac arrest who had initial successful CPR, except to that of minute 60. Tabriz University of Medical Sciences 2016 2016-06-28 /pmc/articles/PMC4970572/ /pubmed/27489598 http://dx.doi.org/10.15171/jcvtr.2016.12 Text en © 2016 The Author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mosaddegh, Reza
Kianmehr, Nahid
Mahshidfar, Babak
Rahmani, Zahra
Aghdam, Hamed
Mofidi, Mani
Serum cortisol level and adrenal reserve as a predictor of patients’ outcome after successful cardiopulmonary resuscitation
title Serum cortisol level and adrenal reserve as a predictor of patients’ outcome after successful cardiopulmonary resuscitation
title_full Serum cortisol level and adrenal reserve as a predictor of patients’ outcome after successful cardiopulmonary resuscitation
title_fullStr Serum cortisol level and adrenal reserve as a predictor of patients’ outcome after successful cardiopulmonary resuscitation
title_full_unstemmed Serum cortisol level and adrenal reserve as a predictor of patients’ outcome after successful cardiopulmonary resuscitation
title_short Serum cortisol level and adrenal reserve as a predictor of patients’ outcome after successful cardiopulmonary resuscitation
title_sort serum cortisol level and adrenal reserve as a predictor of patients’ outcome after successful cardiopulmonary resuscitation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970572/
https://www.ncbi.nlm.nih.gov/pubmed/27489598
http://dx.doi.org/10.15171/jcvtr.2016.12
work_keys_str_mv AT mosaddeghreza serumcortisollevelandadrenalreserveasapredictorofpatientsoutcomeaftersuccessfulcardiopulmonaryresuscitation
AT kianmehrnahid serumcortisollevelandadrenalreserveasapredictorofpatientsoutcomeaftersuccessfulcardiopulmonaryresuscitation
AT mahshidfarbabak serumcortisollevelandadrenalreserveasapredictorofpatientsoutcomeaftersuccessfulcardiopulmonaryresuscitation
AT rahmanizahra serumcortisollevelandadrenalreserveasapredictorofpatientsoutcomeaftersuccessfulcardiopulmonaryresuscitation
AT aghdamhamed serumcortisollevelandadrenalreserveasapredictorofpatientsoutcomeaftersuccessfulcardiopulmonaryresuscitation
AT mofidimani serumcortisollevelandadrenalreserveasapredictorofpatientsoutcomeaftersuccessfulcardiopulmonaryresuscitation