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Serum cortisol level and adrenal reserve as a predictor of patients’ outcome after successful cardiopulmonary resuscitation
Introduction: It is thought that pituitary-adrenal axis has a fundamental role in outcome of cardiopulmonary arrest (CPA). This study designed to evaluate the correlation between adrenal reserve and post-resuscitation outcome. Methods: In this clinical trial study, 52 consecutive patients with CPA w...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tabriz University of Medical Sciences
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970572/ https://www.ncbi.nlm.nih.gov/pubmed/27489598 http://dx.doi.org/10.15171/jcvtr.2016.12 |
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author | Mosaddegh, Reza Kianmehr, Nahid Mahshidfar, Babak Rahmani, Zahra Aghdam, Hamed Mofidi, Mani |
author_facet | Mosaddegh, Reza Kianmehr, Nahid Mahshidfar, Babak Rahmani, Zahra Aghdam, Hamed Mofidi, Mani |
author_sort | Mosaddegh, Reza |
collection | PubMed |
description | Introduction: It is thought that pituitary-adrenal axis has a fundamental role in outcome of cardiopulmonary arrest (CPA). This study designed to evaluate the correlation between adrenal reserve and post-resuscitation outcome. Methods: In this clinical trial study, 52 consecutive patients with CPA were enrolled in two emergency departments (EDs) over a 3-month period. Plasma cortisol level was measured at the beginning of CPR. Intravenous adrenocorticotropic hormone (ACTH) stimulation test was carried out after successful CPR, and blood samples were taken at 30 and 60 minutes, and 24 hours thereafter. Patients were divided into two groups: in-hospital death or hospital discharge. Results: In patients who died, baseline and post-ACTH serum cortisol after 30 and 60 minutes and 24 hours were higher than patients who discharged from the hospital, but it was not statistically significant except to that of minute 60 (P=0.49). A model of multivariate logistic regression analysis showed that age and need for vasopressor infusion correlated with mortality. Conclusion: Current study could not show the statistically significant difference in initial and post-ACTH serum cortisol levels between survivor and non-survivor patients with cardiac arrest who had initial successful CPR, except to that of minute 60. |
format | Online Article Text |
id | pubmed-4970572 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Tabriz University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-49705722016-08-03 Serum cortisol level and adrenal reserve as a predictor of patients’ outcome after successful cardiopulmonary resuscitation Mosaddegh, Reza Kianmehr, Nahid Mahshidfar, Babak Rahmani, Zahra Aghdam, Hamed Mofidi, Mani J Cardiovasc Thorac Res Original Article Introduction: It is thought that pituitary-adrenal axis has a fundamental role in outcome of cardiopulmonary arrest (CPA). This study designed to evaluate the correlation between adrenal reserve and post-resuscitation outcome. Methods: In this clinical trial study, 52 consecutive patients with CPA were enrolled in two emergency departments (EDs) over a 3-month period. Plasma cortisol level was measured at the beginning of CPR. Intravenous adrenocorticotropic hormone (ACTH) stimulation test was carried out after successful CPR, and blood samples were taken at 30 and 60 minutes, and 24 hours thereafter. Patients were divided into two groups: in-hospital death or hospital discharge. Results: In patients who died, baseline and post-ACTH serum cortisol after 30 and 60 minutes and 24 hours were higher than patients who discharged from the hospital, but it was not statistically significant except to that of minute 60 (P=0.49). A model of multivariate logistic regression analysis showed that age and need for vasopressor infusion correlated with mortality. Conclusion: Current study could not show the statistically significant difference in initial and post-ACTH serum cortisol levels between survivor and non-survivor patients with cardiac arrest who had initial successful CPR, except to that of minute 60. Tabriz University of Medical Sciences 2016 2016-06-28 /pmc/articles/PMC4970572/ /pubmed/27489598 http://dx.doi.org/10.15171/jcvtr.2016.12 Text en © 2016 The Author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Mosaddegh, Reza Kianmehr, Nahid Mahshidfar, Babak Rahmani, Zahra Aghdam, Hamed Mofidi, Mani Serum cortisol level and adrenal reserve as a predictor of patients’ outcome after successful cardiopulmonary resuscitation |
title | Serum cortisol level and adrenal reserve as a predictor of patients’ outcome after successful cardiopulmonary resuscitation |
title_full | Serum cortisol level and adrenal reserve as a predictor of patients’ outcome after successful cardiopulmonary resuscitation |
title_fullStr | Serum cortisol level and adrenal reserve as a predictor of patients’ outcome after successful cardiopulmonary resuscitation |
title_full_unstemmed | Serum cortisol level and adrenal reserve as a predictor of patients’ outcome after successful cardiopulmonary resuscitation |
title_short | Serum cortisol level and adrenal reserve as a predictor of patients’ outcome after successful cardiopulmonary resuscitation |
title_sort | serum cortisol level and adrenal reserve as a predictor of patients’ outcome after successful cardiopulmonary resuscitation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970572/ https://www.ncbi.nlm.nih.gov/pubmed/27489598 http://dx.doi.org/10.15171/jcvtr.2016.12 |
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