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Computational Simulation of the Activation Cycle of Gα Subunit in the G Protein Cycle Using an Elastic Network Model
Agonist-activated G protein-coupled receptors (GPCRs) interact with GDP-bound G protein heterotrimers (Gαβγ) promoting GDP/GTP exchange, which results in dissociation of Gα from the receptor and Gβγ. The GTPase activity of Gα hydrolyzes GTP to GDP, and the GDP-bound Gα interacts with Gβγ, forming a...
Autores principales: | Kim, Min Hyeok, Kim, Young Jin, Kim, Hee Ryung, Jeon, Tae-Joon, Choi, Jae Boong, Chung, Ka Young, Kim, Moon Ki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970668/ https://www.ncbi.nlm.nih.gov/pubmed/27483005 http://dx.doi.org/10.1371/journal.pone.0159528 |
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