The Wnt7's Tale: A story of an orphan who finds her tie to a famous family

The transformation suppressor gene RECK was isolated by cDNA expression cloning (1998), and GPR124/TEM5 was detected as a tumor endothelial marker by differential screening (2000). The importance of Wnt7a/b and Gpr124 in brain angiogenesis was demonstrated by reverse genetics in mice (2008–2010). A...

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Detalles Bibliográficos
Autores principales: Noda, Makoto, Vallon, Mario, Kuo, Calvin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970824/
https://www.ncbi.nlm.nih.gov/pubmed/26934061
http://dx.doi.org/10.1111/cas.12924
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author Noda, Makoto
Vallon, Mario
Kuo, Calvin J.
author_facet Noda, Makoto
Vallon, Mario
Kuo, Calvin J.
author_sort Noda, Makoto
collection PubMed
description The transformation suppressor gene RECK was isolated by cDNA expression cloning (1998), and GPR124/TEM5 was detected as a tumor endothelial marker by differential screening (2000). The importance of Wnt7a/b and Gpr124 in brain angiogenesis was demonstrated by reverse genetics in mice (2008–2010). A series of recent studies using genetically engineered mice and zebrafish as well as luciferase reporter assays in cultured cells led to the discovery of functional interactions among Reck, Gpr124, and Wnt7a/b in triggering canonical Wnt signaling with relevance to embryonic brain angiogenesis and blood–brain barrier formation.
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spelling pubmed-49708242016-09-07 The Wnt7's Tale: A story of an orphan who finds her tie to a famous family Noda, Makoto Vallon, Mario Kuo, Calvin J. Cancer Sci Review Articles The transformation suppressor gene RECK was isolated by cDNA expression cloning (1998), and GPR124/TEM5 was detected as a tumor endothelial marker by differential screening (2000). The importance of Wnt7a/b and Gpr124 in brain angiogenesis was demonstrated by reverse genetics in mice (2008–2010). A series of recent studies using genetically engineered mice and zebrafish as well as luciferase reporter assays in cultured cells led to the discovery of functional interactions among Reck, Gpr124, and Wnt7a/b in triggering canonical Wnt signaling with relevance to embryonic brain angiogenesis and blood–brain barrier formation. John Wiley and Sons Inc. 2016-04-07 2016-05 /pmc/articles/PMC4970824/ /pubmed/26934061 http://dx.doi.org/10.1111/cas.12924 Text en © 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review Articles
Noda, Makoto
Vallon, Mario
Kuo, Calvin J.
The Wnt7's Tale: A story of an orphan who finds her tie to a famous family
title The Wnt7's Tale: A story of an orphan who finds her tie to a famous family
title_full The Wnt7's Tale: A story of an orphan who finds her tie to a famous family
title_fullStr The Wnt7's Tale: A story of an orphan who finds her tie to a famous family
title_full_unstemmed The Wnt7's Tale: A story of an orphan who finds her tie to a famous family
title_short The Wnt7's Tale: A story of an orphan who finds her tie to a famous family
title_sort wnt7's tale: a story of an orphan who finds her tie to a famous family
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970824/
https://www.ncbi.nlm.nih.gov/pubmed/26934061
http://dx.doi.org/10.1111/cas.12924
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