Xenotransplantation elicits salient tumorigenicity of adult T‐cell leukemia‐derived cells via aberrant AKT activation

The transplantation of human cancer cells into immunodeficient NOD/SCID/IL‐2Rγc(null) (NOG) mice often causes highly malignant cell populations like cancer stem cells to emerge. Here, by serial transplantation in NOG mice, we established two highly tumorigenic adult T‐cell leukemia‐derived cell line...

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Detalles Bibliográficos
Autores principales: Yamaguchi, Kazunori, Takanashi, Tomoka, Nasu, Kentaro, Tamai, Keiichi, Mochizuki, Mai, Satoh, Ikuro, Ine, Shoji, Sasaki, Osamu, Satoh, Kennichi, Tanaka, Nobuyuki, Harigae, Hideo, Sugamura, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970830/
https://www.ncbi.nlm.nih.gov/pubmed/26928911
http://dx.doi.org/10.1111/cas.12921

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