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Diffuse optical spectroscopic imaging of subcutaneous adipose tissue metabolic changes during weight loss

BACKGROUND: Changes in subcutaneous adipose tissue (AT) structure and metabolism have been shown to correlate with the development of obesity and related metabolic disorders. Measurements of AT physiology could provide new insight into metabolic disease progression and response to therapy. An emergi...

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Autores principales: Ganesan, Goutham, Warren, Robert V., Leproux, Anaïs, Compton, Montana, Cutler, Kyle, Wittkopp, Sharine, Tran, Gerard, O’Sullivan, Thomas, Malik, Shaista, Galassetti, Pietro R., Tromberg, Bruce J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970874/
https://www.ncbi.nlm.nih.gov/pubmed/27089996
http://dx.doi.org/10.1038/ijo.2016.43
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author Ganesan, Goutham
Warren, Robert V.
Leproux, Anaïs
Compton, Montana
Cutler, Kyle
Wittkopp, Sharine
Tran, Gerard
O’Sullivan, Thomas
Malik, Shaista
Galassetti, Pietro R.
Tromberg, Bruce J.
author_facet Ganesan, Goutham
Warren, Robert V.
Leproux, Anaïs
Compton, Montana
Cutler, Kyle
Wittkopp, Sharine
Tran, Gerard
O’Sullivan, Thomas
Malik, Shaista
Galassetti, Pietro R.
Tromberg, Bruce J.
author_sort Ganesan, Goutham
collection PubMed
description BACKGROUND: Changes in subcutaneous adipose tissue (AT) structure and metabolism have been shown to correlate with the development of obesity and related metabolic disorders. Measurements of AT physiology could provide new insight into metabolic disease progression and response to therapy. An emerging functional imaging technology, Diffuse Optical Spectroscopic Imaging (DOSI), was used to obtain quantitative measures of near infrared (NIR) AT optical and physiological properties. METHODS: 10 overweight or obese adults were assessed during three-months on calorie-restricted diets. DOSI-derived tissue concentrations of hemoglobin, water, and lipid and the wavelength-dependent scattering amplitude (A) and slope (b) obtained from 30 abdominal locations and three time points (T0, T6, T12) were calculated and analyzed using linear mixed effects models, and were also used to form 3D surface images. RESULTS: Subjects lost a mean of 11.7 ± 3.4% of starting weight, while significant changes in A (+0.23 ± 0.04 mm(−1), adj. p < 0.001), b (−0.17 ± 0.04, adj. p < 0.001), tissue water fraction (+7.2 ± 1.1%, adj. p < 0.001) and deoxyhemoglobin [HbR] (1.1 ± 0.3 µM, adj. p < 0.001) were observed using mixed effect model analysis. DISCUSSION: Optical scattering signals reveal alterations in tissue structure which possibly correlate with reductions in adipose cell volume, while water and hemoglobin dynamics suggest improved AT perfusion and oxygen extraction. These results suggest that DOSI measurements of NIR optical and physiological properties could be used to enhance understanding of the role of AT in metabolic disorders and provide new strategies for diagnostic monitoring of obesity and weight loss.
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spelling pubmed-49708742016-10-22 Diffuse optical spectroscopic imaging of subcutaneous adipose tissue metabolic changes during weight loss Ganesan, Goutham Warren, Robert V. Leproux, Anaïs Compton, Montana Cutler, Kyle Wittkopp, Sharine Tran, Gerard O’Sullivan, Thomas Malik, Shaista Galassetti, Pietro R. Tromberg, Bruce J. Int J Obes (Lond) Article BACKGROUND: Changes in subcutaneous adipose tissue (AT) structure and metabolism have been shown to correlate with the development of obesity and related metabolic disorders. Measurements of AT physiology could provide new insight into metabolic disease progression and response to therapy. An emerging functional imaging technology, Diffuse Optical Spectroscopic Imaging (DOSI), was used to obtain quantitative measures of near infrared (NIR) AT optical and physiological properties. METHODS: 10 overweight or obese adults were assessed during three-months on calorie-restricted diets. DOSI-derived tissue concentrations of hemoglobin, water, and lipid and the wavelength-dependent scattering amplitude (A) and slope (b) obtained from 30 abdominal locations and three time points (T0, T6, T12) were calculated and analyzed using linear mixed effects models, and were also used to form 3D surface images. RESULTS: Subjects lost a mean of 11.7 ± 3.4% of starting weight, while significant changes in A (+0.23 ± 0.04 mm(−1), adj. p < 0.001), b (−0.17 ± 0.04, adj. p < 0.001), tissue water fraction (+7.2 ± 1.1%, adj. p < 0.001) and deoxyhemoglobin [HbR] (1.1 ± 0.3 µM, adj. p < 0.001) were observed using mixed effect model analysis. DISCUSSION: Optical scattering signals reveal alterations in tissue structure which possibly correlate with reductions in adipose cell volume, while water and hemoglobin dynamics suggest improved AT perfusion and oxygen extraction. These results suggest that DOSI measurements of NIR optical and physiological properties could be used to enhance understanding of the role of AT in metabolic disorders and provide new strategies for diagnostic monitoring of obesity and weight loss. 2016-04-22 2016-08 /pmc/articles/PMC4970874/ /pubmed/27089996 http://dx.doi.org/10.1038/ijo.2016.43 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Ganesan, Goutham
Warren, Robert V.
Leproux, Anaïs
Compton, Montana
Cutler, Kyle
Wittkopp, Sharine
Tran, Gerard
O’Sullivan, Thomas
Malik, Shaista
Galassetti, Pietro R.
Tromberg, Bruce J.
Diffuse optical spectroscopic imaging of subcutaneous adipose tissue metabolic changes during weight loss
title Diffuse optical spectroscopic imaging of subcutaneous adipose tissue metabolic changes during weight loss
title_full Diffuse optical spectroscopic imaging of subcutaneous adipose tissue metabolic changes during weight loss
title_fullStr Diffuse optical spectroscopic imaging of subcutaneous adipose tissue metabolic changes during weight loss
title_full_unstemmed Diffuse optical spectroscopic imaging of subcutaneous adipose tissue metabolic changes during weight loss
title_short Diffuse optical spectroscopic imaging of subcutaneous adipose tissue metabolic changes during weight loss
title_sort diffuse optical spectroscopic imaging of subcutaneous adipose tissue metabolic changes during weight loss
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970874/
https://www.ncbi.nlm.nih.gov/pubmed/27089996
http://dx.doi.org/10.1038/ijo.2016.43
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