Family-based Association Analyses of Imputed Genotypes Reveal Genome-Wide Significant Association of Alzheimer’s disease with OSBPL6, PTPRG and PDCL3

The genetic basis of Alzheimer's disease (AD) is complex and heterogeneous. Over 200 highly penetrant pathogenic variants in the genes APP, PSEN1 and PSEN2 cause a subset of early-onset familial Alzheimer's disease (EOFAD). On the other hand, susceptibility to late-onset forms of AD (LOAD)...

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Detalles Bibliográficos
Autores principales: Herold, Christine, Hooli, Basavaraj V., Mullin, Kristina, Liu, Tian, Roehr, Johannes T, Mattheisen, Manuel, Parrado, Antonio R., Bertram, Lars, Lange, Christoph, Tanzi, Rudolph E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970971/
https://www.ncbi.nlm.nih.gov/pubmed/26830138
http://dx.doi.org/10.1038/mp.2015.218

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