The use of HPLC-Q-TOF-MS for comprehensive screening of drugs and psychoactive substances in hair samples and several “legal highs” products

ABSTRACT: Non-targeted screening of drugs present in herbal products, known as “legal high” drugs and in hair as a biological matrix commonly used in toxicological investigations was accomplished with the use of high pressure liquid chromatography coupled with quadrupole time-of-flight mass spectrom...

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Detalles Bibliográficos
Autores principales: Aszyk, Justyna, Kot-Wasik, Agata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971043/
https://www.ncbi.nlm.nih.gov/pubmed/27546908
http://dx.doi.org/10.1007/s00706-016-1773-z
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author Aszyk, Justyna
Kot-Wasik, Agata
author_facet Aszyk, Justyna
Kot-Wasik, Agata
author_sort Aszyk, Justyna
collection PubMed
description ABSTRACT: Non-targeted screening of drugs present in herbal products, known as “legal high” drugs and in hair as a biological matrix commonly used in toxicological investigations was accomplished with the use of high pressure liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS). In total, 25 and 14 therapeutical drugs and psychoactive substances/metabolites were detected in investigated hair samples and herbal products, respectively. We demonstrate that the HPLC-Q-TOF methodology seems to be a powerful tool in the qualitative analysis applied in identification of these designer drugs, thus enabling a laboratory to stay-up-to-date with the drugs that are being sold as legal high products on black market. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-49710432016-08-17 The use of HPLC-Q-TOF-MS for comprehensive screening of drugs and psychoactive substances in hair samples and several “legal highs” products Aszyk, Justyna Kot-Wasik, Agata Monatsh Chem Original Paper ABSTRACT: Non-targeted screening of drugs present in herbal products, known as “legal high” drugs and in hair as a biological matrix commonly used in toxicological investigations was accomplished with the use of high pressure liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS). In total, 25 and 14 therapeutical drugs and psychoactive substances/metabolites were detected in investigated hair samples and herbal products, respectively. We demonstrate that the HPLC-Q-TOF methodology seems to be a powerful tool in the qualitative analysis applied in identification of these designer drugs, thus enabling a laboratory to stay-up-to-date with the drugs that are being sold as legal high products on black market. GRAPHICAL ABSTRACT: [Image: see text] Springer Vienna 2016-06-07 2016 /pmc/articles/PMC4971043/ /pubmed/27546908 http://dx.doi.org/10.1007/s00706-016-1773-z Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Paper
Aszyk, Justyna
Kot-Wasik, Agata
The use of HPLC-Q-TOF-MS for comprehensive screening of drugs and psychoactive substances in hair samples and several “legal highs” products
title The use of HPLC-Q-TOF-MS for comprehensive screening of drugs and psychoactive substances in hair samples and several “legal highs” products
title_full The use of HPLC-Q-TOF-MS for comprehensive screening of drugs and psychoactive substances in hair samples and several “legal highs” products
title_fullStr The use of HPLC-Q-TOF-MS for comprehensive screening of drugs and psychoactive substances in hair samples and several “legal highs” products
title_full_unstemmed The use of HPLC-Q-TOF-MS for comprehensive screening of drugs and psychoactive substances in hair samples and several “legal highs” products
title_short The use of HPLC-Q-TOF-MS for comprehensive screening of drugs and psychoactive substances in hair samples and several “legal highs” products
title_sort use of hplc-q-tof-ms for comprehensive screening of drugs and psychoactive substances in hair samples and several “legal highs” products
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971043/
https://www.ncbi.nlm.nih.gov/pubmed/27546908
http://dx.doi.org/10.1007/s00706-016-1773-z
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