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Neonatal encephalitis due to Chikungunya vertical transmission: First report in Brazil

PURPOSE: To report the first case of Chikungunya encephalitis acquired in the perinatal period during the current outbreak in Brazil METHODS: Case report. RESULTS: A male neonate with 3500 g developed macular erythematous rash, hypoactivity and fever progressing to generalized seizures. His mother h...

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Autores principales: Bandeira, Antonio Carlos, Campos, Gubio Soares, Sardi, Silvia Ines, Rocha, Veronica França Diniz, Rocha, Guilherme Cesar Mendes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971151/
https://www.ncbi.nlm.nih.gov/pubmed/27500084
http://dx.doi.org/10.1016/j.idcr.2016.07.008
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author Bandeira, Antonio Carlos
Campos, Gubio Soares
Sardi, Silvia Ines
Rocha, Veronica França Diniz
Rocha, Guilherme Cesar Mendes
author_facet Bandeira, Antonio Carlos
Campos, Gubio Soares
Sardi, Silvia Ines
Rocha, Veronica França Diniz
Rocha, Guilherme Cesar Mendes
author_sort Bandeira, Antonio Carlos
collection PubMed
description PURPOSE: To report the first case of Chikungunya encephalitis acquired in the perinatal period during the current outbreak in Brazil METHODS: Case report. RESULTS: A male neonate with 3500 g developed macular erythematous rash, hypoactivity and fever progressing to generalized seizures. His mother had experienced a disseminated rash and fever before delivery. EEG showed diffuse slowing and cranial NMR was suggestive of encephalitis. Rt-PCR for Chikungunya virus (CHIKV) was positive in cerebrospinal fluid (CSF), blood, urine and saliva. The newborn was discharged home with neurological improvement. CONCLUSION: We report the first case of a perinatal CHIKV infection associated with a rapidly evolving encephalitis and an extensive dissemination of the virus as documented by positive rt-PCR results in CSF, blood, urine and saliva in the present outbreak in Brazil. In countries experiencing outbreaks of CHIKV infections, clinicians and neonatologists must be familiar with the possibility of the occurrence of neurologic complications and its possible consequences.
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spelling pubmed-49711512016-08-05 Neonatal encephalitis due to Chikungunya vertical transmission: First report in Brazil Bandeira, Antonio Carlos Campos, Gubio Soares Sardi, Silvia Ines Rocha, Veronica França Diniz Rocha, Guilherme Cesar Mendes IDCases Case Study PURPOSE: To report the first case of Chikungunya encephalitis acquired in the perinatal period during the current outbreak in Brazil METHODS: Case report. RESULTS: A male neonate with 3500 g developed macular erythematous rash, hypoactivity and fever progressing to generalized seizures. His mother had experienced a disseminated rash and fever before delivery. EEG showed diffuse slowing and cranial NMR was suggestive of encephalitis. Rt-PCR for Chikungunya virus (CHIKV) was positive in cerebrospinal fluid (CSF), blood, urine and saliva. The newborn was discharged home with neurological improvement. CONCLUSION: We report the first case of a perinatal CHIKV infection associated with a rapidly evolving encephalitis and an extensive dissemination of the virus as documented by positive rt-PCR results in CSF, blood, urine and saliva in the present outbreak in Brazil. In countries experiencing outbreaks of CHIKV infections, clinicians and neonatologists must be familiar with the possibility of the occurrence of neurologic complications and its possible consequences. Elsevier 2016-07-25 /pmc/articles/PMC4971151/ /pubmed/27500084 http://dx.doi.org/10.1016/j.idcr.2016.07.008 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Study
Bandeira, Antonio Carlos
Campos, Gubio Soares
Sardi, Silvia Ines
Rocha, Veronica França Diniz
Rocha, Guilherme Cesar Mendes
Neonatal encephalitis due to Chikungunya vertical transmission: First report in Brazil
title Neonatal encephalitis due to Chikungunya vertical transmission: First report in Brazil
title_full Neonatal encephalitis due to Chikungunya vertical transmission: First report in Brazil
title_fullStr Neonatal encephalitis due to Chikungunya vertical transmission: First report in Brazil
title_full_unstemmed Neonatal encephalitis due to Chikungunya vertical transmission: First report in Brazil
title_short Neonatal encephalitis due to Chikungunya vertical transmission: First report in Brazil
title_sort neonatal encephalitis due to chikungunya vertical transmission: first report in brazil
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971151/
https://www.ncbi.nlm.nih.gov/pubmed/27500084
http://dx.doi.org/10.1016/j.idcr.2016.07.008
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