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Evaluation of Giardia lamblia thioredoxin reductase as drug activating enzyme and as drug target
The antioxidative enzyme thioredoxin reductase (TrxR) has been suggested to be a drug target in several pathogens, including the protist parasite Giardia lamblia. TrxR is also believed to catalyse the reduction of nitro drugs, e.g. metronidazole and furazolidone, a reaction required to render these...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971154/ https://www.ncbi.nlm.nih.gov/pubmed/27485086 http://dx.doi.org/10.1016/j.ijpddr.2016.07.003 |