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Persistence of Neutralizing Antibody Against Dengue Virus 2 After 70 Years from Infection in Nagasaki

This study aimed to investigate the duration of humoral immune responses to dengue virus (DENV) infection in Japanese who experienced acute febrile illness with hemorrhagic manifestations 70 years ago, when an epidemic of dengue occurred in Nagasaki, Japan, from 1942 to 1944. A Japanese volunteer re...

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Detalles Bibliográficos
Autores principales: Ngwe Tun, Mya Myat, Muta, Yoshihito, Inoue, Shingo, Morita, Kouichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971407/
https://www.ncbi.nlm.nih.gov/pubmed/27493841
http://dx.doi.org/10.1089/biores.2016.0016
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author Ngwe Tun, Mya Myat
Muta, Yoshihito
Inoue, Shingo
Morita, Kouichi
author_facet Ngwe Tun, Mya Myat
Muta, Yoshihito
Inoue, Shingo
Morita, Kouichi
author_sort Ngwe Tun, Mya Myat
collection PubMed
description This study aimed to investigate the duration of humoral immune responses to dengue virus (DENV) infection in Japanese who experienced acute febrile illness with hemorrhagic manifestations 70 years ago, when an epidemic of dengue occurred in Nagasaki, Japan, from 1942 to 1944. A Japanese volunteer requested serological diagnosis of DENV infection in 2014 and donated blood sample to measure the antibody titer against DENV by antiflavi IgG indirect ELISA, focus reduction neutralization test, and plaque reduction neutralization test. The serum sample of the volunteer was positive in flavi IgG ELISA and it indicated primary infection. In the neutralization test, the highest neutralizing titer was ≥218 for DENV-2. We report here the existence of DENV-specific antibodies in the serum of a person after 70 years from infection. Published reports indicated that DENV-1 was responsible for the 1942–1944 outbreak in Nagasaki. However, our data suggested that DENV-2 also played a role in this Nagasaki dengue epidemic.
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spelling pubmed-49714072016-08-04 Persistence of Neutralizing Antibody Against Dengue Virus 2 After 70 Years from Infection in Nagasaki Ngwe Tun, Mya Myat Muta, Yoshihito Inoue, Shingo Morita, Kouichi Biores Open Access Brief Report This study aimed to investigate the duration of humoral immune responses to dengue virus (DENV) infection in Japanese who experienced acute febrile illness with hemorrhagic manifestations 70 years ago, when an epidemic of dengue occurred in Nagasaki, Japan, from 1942 to 1944. A Japanese volunteer requested serological diagnosis of DENV infection in 2014 and donated blood sample to measure the antibody titer against DENV by antiflavi IgG indirect ELISA, focus reduction neutralization test, and plaque reduction neutralization test. The serum sample of the volunteer was positive in flavi IgG ELISA and it indicated primary infection. In the neutralization test, the highest neutralizing titer was ≥218 for DENV-2. We report here the existence of DENV-specific antibodies in the serum of a person after 70 years from infection. Published reports indicated that DENV-1 was responsible for the 1942–1944 outbreak in Nagasaki. However, our data suggested that DENV-2 also played a role in this Nagasaki dengue epidemic. Mary Ann Liebert, Inc. 2016-07-01 /pmc/articles/PMC4971407/ /pubmed/27493841 http://dx.doi.org/10.1089/biores.2016.0016 Text en © Mya Myat Ngwe Tun et al. 2016; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Brief Report
Ngwe Tun, Mya Myat
Muta, Yoshihito
Inoue, Shingo
Morita, Kouichi
Persistence of Neutralizing Antibody Against Dengue Virus 2 After 70 Years from Infection in Nagasaki
title Persistence of Neutralizing Antibody Against Dengue Virus 2 After 70 Years from Infection in Nagasaki
title_full Persistence of Neutralizing Antibody Against Dengue Virus 2 After 70 Years from Infection in Nagasaki
title_fullStr Persistence of Neutralizing Antibody Against Dengue Virus 2 After 70 Years from Infection in Nagasaki
title_full_unstemmed Persistence of Neutralizing Antibody Against Dengue Virus 2 After 70 Years from Infection in Nagasaki
title_short Persistence of Neutralizing Antibody Against Dengue Virus 2 After 70 Years from Infection in Nagasaki
title_sort persistence of neutralizing antibody against dengue virus 2 after 70 years from infection in nagasaki
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971407/
https://www.ncbi.nlm.nih.gov/pubmed/27493841
http://dx.doi.org/10.1089/biores.2016.0016
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