microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer’s disease triple transgenic mice

The abnormal regulation of amyloid-β (Aβ) metabolism (e.g., production, cleavage, clearance) plays a central role in Alzheimer’s disease (AD). Among endogenous factors believed to participate in AD progression are the small regulatory non-coding microRNAs (miRs). In particular, the miR-132/212 clust...

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Detalles Bibliográficos
Autores principales: Hernandez-Rapp, Julia, Rainone, Sara, Goupil, Claudia, Dorval, Véronique, Smith, Pascal Y., Saint-Pierre, Martine, Vallée, Maxime, Planel, Emmanuel, Droit, Arnaud, Calon, Frédéric, Cicchetti, Francesca, Hébert, Sébastien S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971468/
https://www.ncbi.nlm.nih.gov/pubmed/27484949
http://dx.doi.org/10.1038/srep30953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971468/
https://www.ncbi.nlm.nih.gov/pubmed/27484949
http://dx.doi.org/10.1038/srep30953

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