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Efficient Suppression of Hepatitis C Virus Replication by Combination Treatment with miR-122 Antagonism and Direct-acting Antivirals in Cell Culture Systems

Direct-acting antivirals (DAAs) against Hepatitis C virus (HCV) show effective antiviral activity with few side effects. However, the selection of DAA-resistance mutants is a growing problem that needs to be resolved. In contrast, miR-122 antagonism shows extensive antiviral effects among all HCV ge...

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Detalles Bibliográficos
Autores principales:	Liu, Fanwei, Shimakami, Tetsuro, Murai, Kazuhisa, Shirasaki, Takayoshi, Funaki, Masaya, Honda, Masao, Murakami, Seishi, Yi, Minkyung, Tang, Hong, Kaneko, Shuichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971519/ https://www.ncbi.nlm.nih.gov/pubmed/27484655 http://dx.doi.org/10.1038/srep30939

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