hiPSC-derived cardiomyocytes from Brugada Syndrome patients without identified mutations do not exhibit clear cellular electrophysiological abnormalities

Brugada syndrome (BrS) is a rare cardiac rhythm disorder associated with sudden cardiac death. Mutations in the sodium channel gene SCN5A are found in ~20% of cases while mutations in other genes collectively account for <5%. In the remaining patients the genetic defect and the underlying pathoge...

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Detalles Bibliográficos
Autores principales: Veerman, Christiaan C., Mengarelli, Isabella, Guan, Kaomei, Stauske, Michael, Barc, Julien, Tan, Hanno L., Wilde, Arthur A. M., Verkerk, Arie O., Bezzina, Connie R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971529/
https://www.ncbi.nlm.nih.gov/pubmed/27485484
http://dx.doi.org/10.1038/srep30967

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