Bacterial IgA protease-mediated degradation of agIgA1 and agIgA1 immune complexes as a potential therapy for IgA Nephropathy

Mesangial deposition of aberrantly glycosylated IgA1 (agIgA1) and its immune complexes is a key pathogenic mechanism of IgA nephropathy (IgAN). However, treatment of IgAN remains ineffective. We report here that bacteria-derived IgA proteases are capable of degrading these pathogenic agIgA1 and deri...

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Detalles Bibliográficos
Autores principales: Wang, Li, Li, Xueying, Shen, Hongchun, Mao, Nan, Wang, Honglian, Cui, Luke, Cheng, Yuan, Fan, Junming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971536/
https://www.ncbi.nlm.nih.gov/pubmed/27485391
http://dx.doi.org/10.1038/srep30964

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