Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer

BACKGROUND: The basal-like breast cancer (BLBC) subtype is characterized by positive staining for basal mammary epithelial cytokeratin markers, lack of hormone receptor and HER2 expression, and poor prognosis with currently no approved molecularly-targeted therapies. The oncogenic signaling pathways...

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Detalles Bibliográficos
Autores principales: She, Qing-Bai, Gruvberger-Saal, Sofia K., Maurer, Matthew, Chen, Yilun, Jumppanen, Mervi, Su, Tao, Dendy, Meaghan, Lau, Ying-Ka Ingar, Memeo, Lorenzo, Horlings, Hugo M., van de Vijver, Marc J., Isola, Jorma, Hibshoosh, Hanina, Rosen, Neal, Parsons, Ramon, Saal, Lao H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971667/
https://www.ncbi.nlm.nih.gov/pubmed/27484095
http://dx.doi.org/10.1186/s12885-016-2609-2

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