EphA5 and EphA6: regulation of neuronal and spine morphology

BACKGROUND: The Eph family of receptor tyrosine kinases plays important roles in neural development. Previous studies have implicated Eph receptors and their ligands, the ephrins, in neuronal migration, axon bundling and guidance to specific targets, dendritic spine formation and neural plasticity....

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Autores principales: Das, Gitanjali, Yu, Qili, Hui, Ryan, Reuhl, Kenneth, Gale, Nicholas W., Zhou, Renping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971699/
https://www.ncbi.nlm.nih.gov/pubmed/27489614
http://dx.doi.org/10.1186/s13578-016-0115-5
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author Das, Gitanjali
Yu, Qili
Hui, Ryan
Reuhl, Kenneth
Gale, Nicholas W.
Zhou, Renping
author_facet Das, Gitanjali
Yu, Qili
Hui, Ryan
Reuhl, Kenneth
Gale, Nicholas W.
Zhou, Renping
author_sort Das, Gitanjali
collection PubMed
description BACKGROUND: The Eph family of receptor tyrosine kinases plays important roles in neural development. Previous studies have implicated Eph receptors and their ligands, the ephrins, in neuronal migration, axon bundling and guidance to specific targets, dendritic spine formation and neural plasticity. However, specific contributions of EphA5 and EphA6 receptors to the regulation of neuronal cell morphology have not been well studied. RESULTS: Here we show that deletion of EphA5 and EphA6 results in abnormal Golgi staining patterns of cells in the brain, and abnormal spine morphology. CONCLUSION: These observations suggest novel functions of these Eph receptors in the regulation of neuronal and spine structure in brain development and function.
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spelling pubmed-49716992016-08-04 EphA5 and EphA6: regulation of neuronal and spine morphology Das, Gitanjali Yu, Qili Hui, Ryan Reuhl, Kenneth Gale, Nicholas W. Zhou, Renping Cell Biosci Research BACKGROUND: The Eph family of receptor tyrosine kinases plays important roles in neural development. Previous studies have implicated Eph receptors and their ligands, the ephrins, in neuronal migration, axon bundling and guidance to specific targets, dendritic spine formation and neural plasticity. However, specific contributions of EphA5 and EphA6 receptors to the regulation of neuronal cell morphology have not been well studied. RESULTS: Here we show that deletion of EphA5 and EphA6 results in abnormal Golgi staining patterns of cells in the brain, and abnormal spine morphology. CONCLUSION: These observations suggest novel functions of these Eph receptors in the regulation of neuronal and spine structure in brain development and function. BioMed Central 2016-08-02 /pmc/articles/PMC4971699/ /pubmed/27489614 http://dx.doi.org/10.1186/s13578-016-0115-5 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Das, Gitanjali
Yu, Qili
Hui, Ryan
Reuhl, Kenneth
Gale, Nicholas W.
Zhou, Renping
EphA5 and EphA6: regulation of neuronal and spine morphology
title EphA5 and EphA6: regulation of neuronal and spine morphology
title_full EphA5 and EphA6: regulation of neuronal and spine morphology
title_fullStr EphA5 and EphA6: regulation of neuronal and spine morphology
title_full_unstemmed EphA5 and EphA6: regulation of neuronal and spine morphology
title_short EphA5 and EphA6: regulation of neuronal and spine morphology
title_sort epha5 and epha6: regulation of neuronal and spine morphology
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971699/
https://www.ncbi.nlm.nih.gov/pubmed/27489614
http://dx.doi.org/10.1186/s13578-016-0115-5
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