A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase

Serine metabolism is likely to play a critical role in cancer cell growth. A recent study reports the identification of a novel small-molecule inhibitor of serine synthesis that targets 3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme of the serine synthesis pathway, and selectively abroga...

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Detalles Bibliográficos
Autores principales: Mullarky, Edouard, Lairson, Luke L., Cantley, Lewis C., Lyssiotis, Costas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972100/
https://www.ncbi.nlm.nih.gov/pubmed/27652319
http://dx.doi.org/10.1080/23723556.2016.1164280
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author Mullarky, Edouard
Lairson, Luke L.
Cantley, Lewis C.
Lyssiotis, Costas A.
author_facet Mullarky, Edouard
Lairson, Luke L.
Cantley, Lewis C.
Lyssiotis, Costas A.
author_sort Mullarky, Edouard
collection PubMed
description Serine metabolism is likely to play a critical role in cancer cell growth. A recent study reports the identification of a novel small-molecule inhibitor of serine synthesis that targets 3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme of the serine synthesis pathway, and selectively abrogates the proliferation of PHGDH overexpressing breast cancer cells.
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spelling pubmed-49721002017-03-30 A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase Mullarky, Edouard Lairson, Luke L. Cantley, Lewis C. Lyssiotis, Costas A. Mol Cell Oncol Author's View Serine metabolism is likely to play a critical role in cancer cell growth. A recent study reports the identification of a novel small-molecule inhibitor of serine synthesis that targets 3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme of the serine synthesis pathway, and selectively abrogates the proliferation of PHGDH overexpressing breast cancer cells. Taylor & Francis 2016-03-30 /pmc/articles/PMC4972100/ /pubmed/27652319 http://dx.doi.org/10.1080/23723556.2016.1164280 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Mullarky, Edouard
Lairson, Luke L.
Cantley, Lewis C.
Lyssiotis, Costas A.
A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase
title A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase
title_full A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase
title_fullStr A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase
title_full_unstemmed A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase
title_short A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase
title_sort novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972100/
https://www.ncbi.nlm.nih.gov/pubmed/27652319
http://dx.doi.org/10.1080/23723556.2016.1164280
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