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A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase

Serine metabolism is likely to play a critical role in cancer cell growth. A recent study reports the identification of a novel small-molecule inhibitor of serine synthesis that targets 3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme of the serine synthesis pathway, and selectively abroga...

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Detalles Bibliográficos
Autores principales:	Mullarky, Edouard, Lairson, Luke L., Cantley, Lewis C., Lyssiotis, Costas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2016
Materias:	Author's View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972100/ https://www.ncbi.nlm.nih.gov/pubmed/27652319 http://dx.doi.org/10.1080/23723556.2016.1164280

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