The inheritance of centromere identity

CENP-A (Centromere protein A) is a histone H3 variant that epigenetically determines the centromere position, but the mechanism of its centromere inheritance is obscure. We propose that CENP-A ubiquitylation, which is inherited through dimerization between rounds of cell division, is a candidate for...

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Autores principales: Niikura, Yohei, Kitagawa, Risa, Kitagawa, Katsumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972116/
https://www.ncbi.nlm.nih.gov/pubmed/27652331
http://dx.doi.org/10.1080/23723556.2016.1188226
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author Niikura, Yohei
Kitagawa, Risa
Kitagawa, Katsumi
author_facet Niikura, Yohei
Kitagawa, Risa
Kitagawa, Katsumi
author_sort Niikura, Yohei
collection PubMed
description CENP-A (Centromere protein A) is a histone H3 variant that epigenetically determines the centromere position, but the mechanism of its centromere inheritance is obscure. We propose that CENP-A ubiquitylation, which is inherited through dimerization between rounds of cell division, is a candidate for the epigenetic mark of centromere identity.
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spelling pubmed-49721162017-06-10 The inheritance of centromere identity Niikura, Yohei Kitagawa, Risa Kitagawa, Katsumi Mol Cell Oncol Author's View CENP-A (Centromere protein A) is a histone H3 variant that epigenetically determines the centromere position, but the mechanism of its centromere inheritance is obscure. We propose that CENP-A ubiquitylation, which is inherited through dimerization between rounds of cell division, is a candidate for the epigenetic mark of centromere identity. Taylor & Francis 2016-06-10 /pmc/articles/PMC4972116/ /pubmed/27652331 http://dx.doi.org/10.1080/23723556.2016.1188226 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Niikura, Yohei
Kitagawa, Risa
Kitagawa, Katsumi
The inheritance of centromere identity
title The inheritance of centromere identity
title_full The inheritance of centromere identity
title_fullStr The inheritance of centromere identity
title_full_unstemmed The inheritance of centromere identity
title_short The inheritance of centromere identity
title_sort inheritance of centromere identity
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972116/
https://www.ncbi.nlm.nih.gov/pubmed/27652331
http://dx.doi.org/10.1080/23723556.2016.1188226
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