Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia

Sequencing studies have been instrumental in understanding the genetic basis of chronic lymphocytic leukemia (CLL). Our recent whole-genome sequencing study focusing on lower cytogenetic risk CLL demonstrated that CLL mutations can be attributed to 3 key mutational processes—2 types of activation in...

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Detalles Bibliográficos
Autores principales: Kasar, S., Brown, J. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972118/
https://www.ncbi.nlm.nih.gov/pubmed/27652313
http://dx.doi.org/10.1080/23723556.2016.1157667
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author Kasar, S.
Brown, J. R.
author_facet Kasar, S.
Brown, J. R.
author_sort Kasar, S.
collection PubMed
description Sequencing studies have been instrumental in understanding the genetic basis of chronic lymphocytic leukemia (CLL). Our recent whole-genome sequencing study focusing on lower cytogenetic risk CLL demonstrated that CLL mutations can be attributed to 3 key mutational processes—2 types of activation induced-cytidine deaminase (AID) signatures and an aging signature—that operate at different times throughout CLL evolution.
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spelling pubmed-49721182017-03-10 Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia Kasar, S. Brown, J. R. Mol Cell Oncol Commentary Sequencing studies have been instrumental in understanding the genetic basis of chronic lymphocytic leukemia (CLL). Our recent whole-genome sequencing study focusing on lower cytogenetic risk CLL demonstrated that CLL mutations can be attributed to 3 key mutational processes—2 types of activation induced-cytidine deaminase (AID) signatures and an aging signature—that operate at different times throughout CLL evolution. Taylor & Francis 2016-03-10 /pmc/articles/PMC4972118/ /pubmed/27652313 http://dx.doi.org/10.1080/23723556.2016.1157667 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Commentary
Kasar, S.
Brown, J. R.
Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia
title Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia
title_full Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia
title_fullStr Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia
title_full_unstemmed Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia
title_short Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia
title_sort mutational landscape and underlying mutational processes in chronic lymphocytic leukemia
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972118/
https://www.ncbi.nlm.nih.gov/pubmed/27652313
http://dx.doi.org/10.1080/23723556.2016.1157667
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