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BRCA1-CtIP interaction in the repair of DNA double-strand breaks

DNA termini at double-strand breaks are often chemically heterogeneous and require processing before initiation of repair. In a recent report, we demonstrated that CtIP and the MRE11-RAD50-NBS1 (MRN) nuclease complex cooperate with BRCA1 to specifically repair topoisomerase II-DNA adducted breaks. I...

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Detalles Bibliográficos
Autores principales:	Aparicio, Tomas, Gautier, Jean
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2016
Materias:	Author's View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972120/ https://www.ncbi.nlm.nih.gov/pubmed/27652321 http://dx.doi.org/10.1080/23723556.2016.1169343

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