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Pharmacokinetic/pharmacodynamic modelling of the antimalarial effect of Actelion‐451840 in an induced blood stage malaria study in healthy subjects

AIMS: The aim of this study was to use data from an experimental induced blood stage malaria clinical trial to characterize the antimalarial activity of the new compound Actelion‐451840 using pharmacokinetic/pharmacodynamic (PK/PD) modelling. Then, using simulations from the model, the dose and dosi...

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Detalles Bibliográficos
Autores principales:	Krause, Andreas, Dingemanse, Jasper, Mathis, Alexandre, Marquart, Louise, Möhrle, Jörg J., McCarthy, James S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Pharmacokinetic Dynamic Relationships
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972157/ https://www.ncbi.nlm.nih.gov/pubmed/27062080 http://dx.doi.org/10.1111/bcp.12962

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