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Effect of the Chronic Use of Lithium Carbonate on Induced Tooth Movement in Wistar Rats
Patients who seek dental treatment may have bipolar disorder, and lithium carbonate (LC) is the drug of choice used in the treatment of this disorder. Taking into consideration the controversial results found in the literature, and the possible influence of LC on induced tooth movement, the objectiv...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972349/ https://www.ncbi.nlm.nih.gov/pubmed/27487121 http://dx.doi.org/10.1371/journal.pone.0160400 |
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author | da Silva Kagy, Viviane Trevisan Bittencourt Muniz, Luciana Michels, Arieli Carini Luiz, Suelen Teixeira Reis Azevedo Alanis, Luciana Brancher, João Armando Grégio, Ana Maria Trindade Ignácio, Sérgio Aparecido Camargo, Elisa Souza Machado, Maria Ângela Naval Johann, Aline Cristina Batista Rodrigues |
author_facet | da Silva Kagy, Viviane Trevisan Bittencourt Muniz, Luciana Michels, Arieli Carini Luiz, Suelen Teixeira Reis Azevedo Alanis, Luciana Brancher, João Armando Grégio, Ana Maria Trindade Ignácio, Sérgio Aparecido Camargo, Elisa Souza Machado, Maria Ângela Naval Johann, Aline Cristina Batista Rodrigues |
author_sort | da Silva Kagy, Viviane |
collection | PubMed |
description | Patients who seek dental treatment may have bipolar disorder, and lithium carbonate (LC) is the drug of choice used in the treatment of this disorder. Taking into consideration the controversial results found in the literature, and the possible influence of LC on induced tooth movement, the objective was to evaluate tooth movement induced in rats after administration of lithium carbonate. One hundred and ninety-two rats were divided into 3 groups. In the L group, the animals received daily 60mg/kg of LC, they were not subjected to orthodontic movement, and they were euthanized after 33, 37, 44 or 51 days. In the LM group, the LC was administered for 30 days and during the subsequent 3, 7, 14 and 21 days, corresponding to the period of induced tooth movement, and they received a spring that produced a 30cN force. In the SM group, saline solution was applied. Measurements were made of tooth displacement, the numbers of osteoclasts and serum lithium phosphate (PO4), alkaline phosphatase (ALP) and creatinine levels. The tooth displacement was lower in the LM group compared to the SM group at 44 days. A tendency toward reduction in the number of osteoclasts was observed in the LM group compared to the SM group at 44 days. The average lithium were higher in the L and LM groups compared to the SM group. The opposite was observed for the PO(4) group. A higher value for the ALP was found in the L group. The average creatinine level was lower in the LM group. LC inhibited tooth movement for 14 days, possibly due to the reduction in the number of osteoclasts. |
format | Online Article Text |
id | pubmed-4972349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-49723492016-08-18 Effect of the Chronic Use of Lithium Carbonate on Induced Tooth Movement in Wistar Rats da Silva Kagy, Viviane Trevisan Bittencourt Muniz, Luciana Michels, Arieli Carini Luiz, Suelen Teixeira Reis Azevedo Alanis, Luciana Brancher, João Armando Grégio, Ana Maria Trindade Ignácio, Sérgio Aparecido Camargo, Elisa Souza Machado, Maria Ângela Naval Johann, Aline Cristina Batista Rodrigues PLoS One Research Article Patients who seek dental treatment may have bipolar disorder, and lithium carbonate (LC) is the drug of choice used in the treatment of this disorder. Taking into consideration the controversial results found in the literature, and the possible influence of LC on induced tooth movement, the objective was to evaluate tooth movement induced in rats after administration of lithium carbonate. One hundred and ninety-two rats were divided into 3 groups. In the L group, the animals received daily 60mg/kg of LC, they were not subjected to orthodontic movement, and they were euthanized after 33, 37, 44 or 51 days. In the LM group, the LC was administered for 30 days and during the subsequent 3, 7, 14 and 21 days, corresponding to the period of induced tooth movement, and they received a spring that produced a 30cN force. In the SM group, saline solution was applied. Measurements were made of tooth displacement, the numbers of osteoclasts and serum lithium phosphate (PO4), alkaline phosphatase (ALP) and creatinine levels. The tooth displacement was lower in the LM group compared to the SM group at 44 days. A tendency toward reduction in the number of osteoclasts was observed in the LM group compared to the SM group at 44 days. The average lithium were higher in the L and LM groups compared to the SM group. The opposite was observed for the PO(4) group. A higher value for the ALP was found in the L group. The average creatinine level was lower in the LM group. LC inhibited tooth movement for 14 days, possibly due to the reduction in the number of osteoclasts. Public Library of Science 2016-08-03 /pmc/articles/PMC4972349/ /pubmed/27487121 http://dx.doi.org/10.1371/journal.pone.0160400 Text en © 2016 da Silva Kagy et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article da Silva Kagy, Viviane Trevisan Bittencourt Muniz, Luciana Michels, Arieli Carini Luiz, Suelen Teixeira Reis Azevedo Alanis, Luciana Brancher, João Armando Grégio, Ana Maria Trindade Ignácio, Sérgio Aparecido Camargo, Elisa Souza Machado, Maria Ângela Naval Johann, Aline Cristina Batista Rodrigues Effect of the Chronic Use of Lithium Carbonate on Induced Tooth Movement in Wistar Rats |
title | Effect of the Chronic Use of Lithium Carbonate on Induced Tooth Movement in Wistar Rats |
title_full | Effect of the Chronic Use of Lithium Carbonate on Induced Tooth Movement in Wistar Rats |
title_fullStr | Effect of the Chronic Use of Lithium Carbonate on Induced Tooth Movement in Wistar Rats |
title_full_unstemmed | Effect of the Chronic Use of Lithium Carbonate on Induced Tooth Movement in Wistar Rats |
title_short | Effect of the Chronic Use of Lithium Carbonate on Induced Tooth Movement in Wistar Rats |
title_sort | effect of the chronic use of lithium carbonate on induced tooth movement in wistar rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972349/ https://www.ncbi.nlm.nih.gov/pubmed/27487121 http://dx.doi.org/10.1371/journal.pone.0160400 |
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