Temporal Dynamics of CD8(+) T Cell Effector Responses during Primary HIV Infection

The loss of HIV-specific CD8(+) T cell cytolytic function is a primary factor underlying progressive HIV infection, but whether HIV-specific CD8(+) T cells initially possess cytolytic effector capacity, and when and why this may be lost during infection, is unclear. Here, we assessed CD8(+) T cell f...

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Detalles Bibliográficos
Autores principales: Demers, Korey R., Makedonas, George, Buggert, Marcus, Eller, Michael A., Ratcliffe, Sarah J., Goonetilleke, Nilu, Li, Chris K., Eller, Leigh Anne, Rono, Kathleen, Maganga, Lucas, Nitayaphan, Sorachai, Kibuuka, Hannah, Routy, Jean-Pierre, Slifka, Mark K., Haynes, Barton F., McMichael, Andrew J., Bernard, Nicole F., Robb, Merlin L., Betts, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972399/
https://www.ncbi.nlm.nih.gov/pubmed/27486665
http://dx.doi.org/10.1371/journal.ppat.1005805

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