NKX6.3 Is a Transcription Factor for Wnt/β-catenin and Rho-GTPase Signaling-Related Genes to Suppress Gastric Cancer Progression

Despite ongoing research and recent progress, the prognosis for patients with advanced gastric cancer remains poor. Wnt/β-catenin and Rho-GTPase signaling pathways are known to play essential roles in malignant transformation and progression of various tumors, including gastric cancer. Here, we iden...

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Autores principales: Yoon, Jung Hwan, Eun, Jung Woo, Choi, Won Suk, Kim, Olga, Nam, Suk Woo, Lee, Jung Young, Park, Won Sang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972521/
https://www.ncbi.nlm.nih.gov/pubmed/27333045
http://dx.doi.org/10.1016/j.ebiom.2016.05.027
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author Yoon, Jung Hwan
Eun, Jung Woo
Choi, Won Suk
Kim, Olga
Nam, Suk Woo
Lee, Jung Young
Park, Won Sang
author_facet Yoon, Jung Hwan
Eun, Jung Woo
Choi, Won Suk
Kim, Olga
Nam, Suk Woo
Lee, Jung Young
Park, Won Sang
author_sort Yoon, Jung Hwan
collection PubMed
description Despite ongoing research and recent progress, the prognosis for patients with advanced gastric cancer remains poor. Wnt/β-catenin and Rho-GTPase signaling pathways are known to play essential roles in malignant transformation and progression of various tumors, including gastric cancer. Here, we identify that NKX6 transcription factor, locus 3 (NKX6.3) binds directly to specific promoter regions of Wnt/β-catenin and Rho-GTPase pathway-related genes, resulting in inhibition of cancer cell migration and invasion. Additionally, we find that the expression level of NKX6.3 is involved in regulation of gastric cancer progression and expression of Wnt/β-catenin and Rho-GTPase pathway-related genes in clinical samples. These results suggest that NKX6.3 prevents EMT and cell migration, implying that NKX6.3 inactivation might be one of the key mechanisms of gastric cancer cell invasion and metastasis.
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spelling pubmed-49725212016-08-10 NKX6.3 Is a Transcription Factor for Wnt/β-catenin and Rho-GTPase Signaling-Related Genes to Suppress Gastric Cancer Progression Yoon, Jung Hwan Eun, Jung Woo Choi, Won Suk Kim, Olga Nam, Suk Woo Lee, Jung Young Park, Won Sang EBioMedicine Research Paper Despite ongoing research and recent progress, the prognosis for patients with advanced gastric cancer remains poor. Wnt/β-catenin and Rho-GTPase signaling pathways are known to play essential roles in malignant transformation and progression of various tumors, including gastric cancer. Here, we identify that NKX6 transcription factor, locus 3 (NKX6.3) binds directly to specific promoter regions of Wnt/β-catenin and Rho-GTPase pathway-related genes, resulting in inhibition of cancer cell migration and invasion. Additionally, we find that the expression level of NKX6.3 is involved in regulation of gastric cancer progression and expression of Wnt/β-catenin and Rho-GTPase pathway-related genes in clinical samples. These results suggest that NKX6.3 prevents EMT and cell migration, implying that NKX6.3 inactivation might be one of the key mechanisms of gastric cancer cell invasion and metastasis. Elsevier 2016-05-25 /pmc/articles/PMC4972521/ /pubmed/27333045 http://dx.doi.org/10.1016/j.ebiom.2016.05.027 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Paper
Yoon, Jung Hwan
Eun, Jung Woo
Choi, Won Suk
Kim, Olga
Nam, Suk Woo
Lee, Jung Young
Park, Won Sang
NKX6.3 Is a Transcription Factor for Wnt/β-catenin and Rho-GTPase Signaling-Related Genes to Suppress Gastric Cancer Progression
title NKX6.3 Is a Transcription Factor for Wnt/β-catenin and Rho-GTPase Signaling-Related Genes to Suppress Gastric Cancer Progression
title_full NKX6.3 Is a Transcription Factor for Wnt/β-catenin and Rho-GTPase Signaling-Related Genes to Suppress Gastric Cancer Progression
title_fullStr NKX6.3 Is a Transcription Factor for Wnt/β-catenin and Rho-GTPase Signaling-Related Genes to Suppress Gastric Cancer Progression
title_full_unstemmed NKX6.3 Is a Transcription Factor for Wnt/β-catenin and Rho-GTPase Signaling-Related Genes to Suppress Gastric Cancer Progression
title_short NKX6.3 Is a Transcription Factor for Wnt/β-catenin and Rho-GTPase Signaling-Related Genes to Suppress Gastric Cancer Progression
title_sort nkx6.3 is a transcription factor for wnt/β-catenin and rho-gtpase signaling-related genes to suppress gastric cancer progression
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972521/
https://www.ncbi.nlm.nih.gov/pubmed/27333045
http://dx.doi.org/10.1016/j.ebiom.2016.05.027
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