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Ligand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1
The innate immune protein Stimulator of interferon genes (STING) promotes the induction of interferon beta (IFN-β) production via the phosphorylation of its C-terminal tail (CTT) by TANK-binding kinase 1 (TBK1). Potent ligands of STING are, therefore, promising candidates for novel anti-cancer drugs...
Autores principales: | Tsuchiya, Yuko, Jounai, Nao, Takeshita, Fumihiko, Ishii, Ken J., Mizuguchi, Kenji |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972534/ https://www.ncbi.nlm.nih.gov/pubmed/27333035 http://dx.doi.org/10.1016/j.ebiom.2016.05.039 |
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