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Structure-Based Drug Discovery for Prion Disease Using a Novel Binding Simulation

The accumulation of abnormal prion protein (PrP(Sc)) converted from the normal cellular isoform of PrP (PrP(C)) is assumed to induce pathogenesis in prion diseases. Therefore, drug discovery studies for these diseases have focused on the protein conversion process. We used a structure-based drug dis...

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Detalles Bibliográficos
Autores principales:	Ishibashi, Daisuke, Nakagaki, Takehiro, Ishikawa, Takeshi, Atarashi, Ryuichiro, Watanabe, Ken, Cruz, Felipe A., Hamada, Tsuyoshi, Nishida, Noriyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972544/ https://www.ncbi.nlm.nih.gov/pubmed/27333028 http://dx.doi.org/10.1016/j.ebiom.2016.06.010

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