Histidine-Rich Glycoprotein Prevents Septic Lethality through Regulation of Immunothrombosis and Inflammation

Sepsis is a major cause of death worldwide. We show that a plasma protein histidine-rich glycoprotein (HRG) was decreased significantly in septic mice with cecal ligation and puncture (CLP) and supplementary treatment of septic mice with exogenous HRG improved survival, with strong inhibition of tig...

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Detalles Bibliográficos
Autores principales: Wake, Hidenori, Mori, Shuji, Liu, Keyue, Morioka, Yuta, Teshigawara, Kiyoshi, Sakaguchi, Masakiyo, Kuroda, Kosuke, Gao, Yuan, Takahashi, Hideo, Ohtsuka, Aiji, Yoshino, Tadashi, Morimatsu, Hiroshi, Nishibori, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972547/
https://www.ncbi.nlm.nih.gov/pubmed/27333033
http://dx.doi.org/10.1016/j.ebiom.2016.06.003

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