Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment

Non-small cell lung cancer (NSCLC) is one of the deadliest cancers worldwide. In search for new NSCLC treatment options, we screened a cationic amphiphilic drug (CAD) library for cytotoxicity against NSCLC cells and identified several CAD antihistamines as inducers of lysosomal cell death. We then p...

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Detalles Bibliográficos
Autores principales: Ellegaard, Anne-Marie, Dehlendorff, Christian, Vind, Anna C., Anand, Atul, Cederkvist, Luise, Petersen, Nikolaj H.T., Nylandsted, Jesper, Stenvang, Jan, Mellemgaard, Anders, Østerlind, Kell, Friis, Søren, Jäättelä, Marja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972561/
https://www.ncbi.nlm.nih.gov/pubmed/27333030
http://dx.doi.org/10.1016/j.ebiom.2016.06.013

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