Cargando…

GATA-3 REGULATES THE SELF-RENEWAL OF LONG-TERM HEMATOPOIETIC STEM CELLS

Gata3 is expressed and required for differentiation and function throughout the T lymphocyte lineage. Despite evidence it may also be expressed in multipotent hematopoietic stem cells (HSC), any role in these cells has remained unclear. Here we show GATA3 was cytoplasmic in quiescent long-term stem...

Descripción completa

Detalles Bibliográficos
Autores principales:	Frelin, Catherine, Herrington, Robert, Janmohamed, Salima, Barbara, Mary, Tran, Gary, Paige, Christopher J., Benveniste, Patricia, Zuñiga-Pflücker, Juan-Carlos, Souabni, Abdallah, Busslinger, Meinrad, Iscove, Norman N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972578/ https://www.ncbi.nlm.nih.gov/pubmed/23974957 http://dx.doi.org/10.1038/ni.2692

Ejemplares similares

Neurokinin-1 Receptor Signalling Impacts Bone Marrow Repopulation Efficiency
por: Berger, Alexandra, et al.
Publicado: (2013)

Hoxa9 Transduction Induces Hematopoietic Stem and Progenitor Cell Activity through Direct Down-Regulation of Geminin Protein
por: Ohno, Yoshinori, et al.
Publicado: (2013)

CDK6 Levels Regulate Quiescence Exit in Human Hematopoietic Stem Cells
por: Laurenti, Elisa, et al.
Publicado: (2015)

Essential role of EBF1 in the generation and function of distinct mature B cell types
por: Vilagos, Bojan, et al.
Publicado: (2012)

Gata2 +9.5 enhancer regulates adult hematopoietic stem cell self-renewal and T-cell development
por: You, Xiaona, et al.
Publicado: (2022)

Gata3 Acts Downstream of β-Catenin Signaling to Prevent Ectopic Metanephric Kidney Induction
por: Grote, David, et al.
Publicado: (2008)

Editorial: Molecular switches of the immune system: The E-protein/Id axis in hematopoietic development and function
por: Sigvardsson, Mikael, et al.
Publicado: (2022)

Human CD8 T cells generated in vitro from hematopoietic stem cells are functionally mature
por: Awong, Génève, et al.
Publicado: (2011)

Essential role of the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells
por: Kreslavsky, Taras, et al.
Publicado: (2017)

Mathematical modeling of GATA-switching for regulating the differentiation of hematopoietic stem cell
por: Tian, Tianhai, et al.
Publicado: (2014)

GATA1 controls numbers of hematopoietic progenitors and their response to autoimmune neuroinflammation
por: Hwang, Daniel, et al.
Publicado: (2022)

Early Function of Pax5 (BSAP) before the Pre-B Cell Receptor Stage of B Lymphopoiesis
por: Thévenin, Claire, et al.
Publicado: (1998)

T cell development runs marrow deep
por: Zúñiga-Pflücker, Juan Carlos
Publicado: (2015)

New role identified for LRR-containing proteins in T cell development
por: Zúñiga-Pflücker, Juan-Carlos
Publicado: (2014)

In Vitro Self-Renewal Division of Hematopoietic Stem Cells
por: Ema, Hideo, et al.
Publicado: (2000)

Heterogeneity, Self-Renewal, and Differentiation of Hematopoietic Stem Cells
por: Jurecic, Roland, et al.
Publicado: (2012)

Repercussion of Megakaryocyte-Specific Gata1 Loss on Megakaryopoiesis and the Hematopoietic Precursor Compartment
por: Meinders, Marjolein, et al.
Publicado: (2016)

GATA2 Is Dispensable for Specification of Hemogenic Endothelium but Promotes Endothelial-to-Hematopoietic Transition
por: Kang, HyunJun, et al.
Publicado: (2018)

GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm
por: Castaño, Julio, et al.
Publicado: (2019)

Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development
por: Bresciani, Erica, et al.
Publicado: (2021)

Endothelial-specific Gata3 expression is required for hematopoietic stem cell generation
por: Zaidan, Nada, et al.
Publicado: (2022)

Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsufficiency
por: Rein, Avigail, et al.
Publicado: (2022)

Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal
por: Jose, Lorena Hidalgo San, et al.
Publicado: (2020)

The Clinical Spectrum, Diagnosis, and Management of GATA2 Deficiency
por: Santiago, Marta, et al.
Publicado: (2023)

A highly conserved regulatory element controls hematopoietic expression of GATA-2 in zebrafish
por: Yang, Zhongan, et al.
Publicado: (2007)

Differential coregulator requirements for function of the hematopoietic transcription factor GATA-1 at endogenous loci
por: Pope, Nathaniel J., et al.
Publicado: (2010)

Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo
por: Gao, Xin, et al.
Publicado: (2013)

Contribution of a GATA4-Expressing Hematopoietic Progenitor Lineage to the Adult Mouse Endothelium
por: Carmona, Rita, et al.
Publicado: (2020)

Hematopoietic stem cell transplantation in children and adolescents with GATA2-related myelodysplastic syndrome
por: Bortnick, Rachel, et al.
Publicado: (2021)

Smad4 is critical for self-renewal of hematopoietic stem cells
por: Karlsson, Göran, et al.
Publicado: (2007)

Microdroplet-based one-step RT-PCR for ultrahigh throughput single-cell multiplex gene expression analysis and rare cell detection
por: Ma, Jennifer, et al.
Publicado: (2021)

Essential role of the Pax5 C-terminal domain in controlling B cell commitment and development
por: Gruenbacher, Sarah, et al.
Publicado: (2023)

High-Oxygen Submersion Fetal Thymus Organ Cultures Enable FOXN1-Dependent and -Independent Support of T Lymphopoiesis
por: Han, Jianxun, et al.
Publicado: (2021)

Thymic Microenvironment: Interactions Between Innate Immune Cells and Developing Thymocytes
por: Wang, Helen, et al.
Publicado: (2022)

Characterization of the developing small intestine in the absence of either GATA4 or GATA6
por: Walker, Emily M, et al.
Publicado: (2014)

GATA-2 Plays Two Functionally Distinct Roles during the Ontogeny of Hematopoietic Stem Cells
por: Ling, Kam-Wing, et al.
Publicado: (2004)

GATA2(−/−) human ESCs undergo attenuated endothelial to hematopoietic transition and thereafter granulocyte commitment
por: Huang, Ke, et al.
Publicado: (2015)

Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes
por: Chong, C-E, et al.
Publicado: (2018)

In vivo single cell analysis reveals Gata2 dynamics in cells transitioning to hematopoietic fate
por: Eich, Christina, et al.
Publicado: (2018)

A Novel GATA2 Protein Reporter Mouse Reveals Hematopoietic Progenitor Cell Types
por: Ahmed, Nouraiz, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_rk5r1k51n6r5r0ajpuga4akoet