Draft Genome Sequence of a Metronidazole-Resistant Derivative of Gardnerella vaginalis Strain ATCC 14019

We report the genome sequence of a metronidazole-resistant derivative of Gardnerella vaginalis ATCC 14019. This strain was obtained after serial selection to increase the MIC from 4 to ≥500 µg/ml. Two coding changes, in genes encoding a response regulator and an NAD(+) synthetase, arose during selec...

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Detalles Bibliográficos
Autores principales: Schuyler, Jessica A., Mordechai, Eli, Adelson, Martin E., Gygax, Scott E., Hilbert, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2015
Materias:
Prokaryotes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972788/
https://www.ncbi.nlm.nih.gov/pubmed/26564054
http://dx.doi.org/10.1128/genomeA.01345-15
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author Schuyler, Jessica A.
Mordechai, Eli
Adelson, Martin E.
Gygax, Scott E.
Hilbert, David W.
author_facet Schuyler, Jessica A.
Mordechai, Eli
Adelson, Martin E.
Gygax, Scott E.
Hilbert, David W.
author_sort Schuyler, Jessica A.
collection PubMed
description We report the genome sequence of a metronidazole-resistant derivative of Gardnerella vaginalis ATCC 14019. This strain was obtained after serial selection to increase the MIC from 4 to ≥500 µg/ml. Two coding changes, in genes encoding a response regulator and an NAD(+) synthetase, arose during selection.
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spelling pubmed-49727882016-08-08 Draft Genome Sequence of a Metronidazole-Resistant Derivative of Gardnerella vaginalis Strain ATCC 14019 Schuyler, Jessica A. Mordechai, Eli Adelson, Martin E. Gygax, Scott E. Hilbert, David W. Genome Announc Prokaryotes We report the genome sequence of a metronidazole-resistant derivative of Gardnerella vaginalis ATCC 14019. This strain was obtained after serial selection to increase the MIC from 4 to ≥500 µg/ml. Two coding changes, in genes encoding a response regulator and an NAD(+) synthetase, arose during selection. American Society for Microbiology 2015-11-12 /pmc/articles/PMC4972788/ /pubmed/26564054 http://dx.doi.org/10.1128/genomeA.01345-15 Text en Copyright © 2015 Schuyler et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Prokaryotes
Schuyler, Jessica A.
Mordechai, Eli
Adelson, Martin E.
Gygax, Scott E.
Hilbert, David W.
Draft Genome Sequence of a Metronidazole-Resistant Derivative of Gardnerella vaginalis Strain ATCC 14019
title Draft Genome Sequence of a Metronidazole-Resistant Derivative of Gardnerella vaginalis Strain ATCC 14019
title_full Draft Genome Sequence of a Metronidazole-Resistant Derivative of Gardnerella vaginalis Strain ATCC 14019
title_fullStr Draft Genome Sequence of a Metronidazole-Resistant Derivative of Gardnerella vaginalis Strain ATCC 14019
title_full_unstemmed Draft Genome Sequence of a Metronidazole-Resistant Derivative of Gardnerella vaginalis Strain ATCC 14019
title_short Draft Genome Sequence of a Metronidazole-Resistant Derivative of Gardnerella vaginalis Strain ATCC 14019
title_sort draft genome sequence of a metronidazole-resistant derivative of gardnerella vaginalis strain atcc 14019
topic Prokaryotes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972788/
https://www.ncbi.nlm.nih.gov/pubmed/26564054
http://dx.doi.org/10.1128/genomeA.01345-15
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