The role of EGFR-TKI for leptomeningeal metastases from non-small cell lung cancer

Leptomeningeal metastasis (LM) is a terminal event in the development of non-small cell lung cancer (NSCLC). It has a poor prognosis with median survival of 1.9 months if untreated. The improvement of OS in NSCLC patients relatively increases incidence of LM. While current therapeutic options for LM...

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Autores principales: Yufen, Xu, Binbin, Song, Wenyu, Chen, Jialiang, Liu, Xinmei, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972805/
https://www.ncbi.nlm.nih.gov/pubmed/27536527
http://dx.doi.org/10.1186/s40064-016-2873-2
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author Yufen, Xu
Binbin, Song
Wenyu, Chen
Jialiang, Liu
Xinmei, Yang
author_facet Yufen, Xu
Binbin, Song
Wenyu, Chen
Jialiang, Liu
Xinmei, Yang
author_sort Yufen, Xu
collection PubMed
description Leptomeningeal metastasis (LM) is a terminal event in the development of non-small cell lung cancer (NSCLC). It has a poor prognosis with median survival of 1.9 months if untreated. The improvement of OS in NSCLC patients relatively increases incidence of LM. While current therapeutic options for LM are limited. Epidermal growth factor receptor-tyrosine kinase inhibitors are a class of small molecules and show dramatic response in epidermal growth factor receptor mutated patients. It also has a distinct therapeutic potential against brain metastases. Although there are some studies on EGFR-TKIs and brain metastases, the role of EGFR-TKIs on LM are not fully clarified. In this review, we will summarize current evidences concerning the use and discuss the role of EGFR-TKIs on LM.
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spelling pubmed-49728052016-08-17 The role of EGFR-TKI for leptomeningeal metastases from non-small cell lung cancer Yufen, Xu Binbin, Song Wenyu, Chen Jialiang, Liu Xinmei, Yang Springerplus Review Leptomeningeal metastasis (LM) is a terminal event in the development of non-small cell lung cancer (NSCLC). It has a poor prognosis with median survival of 1.9 months if untreated. The improvement of OS in NSCLC patients relatively increases incidence of LM. While current therapeutic options for LM are limited. Epidermal growth factor receptor-tyrosine kinase inhibitors are a class of small molecules and show dramatic response in epidermal growth factor receptor mutated patients. It also has a distinct therapeutic potential against brain metastases. Although there are some studies on EGFR-TKIs and brain metastases, the role of EGFR-TKIs on LM are not fully clarified. In this review, we will summarize current evidences concerning the use and discuss the role of EGFR-TKIs on LM. Springer International Publishing 2016-08-03 /pmc/articles/PMC4972805/ /pubmed/27536527 http://dx.doi.org/10.1186/s40064-016-2873-2 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Yufen, Xu
Binbin, Song
Wenyu, Chen
Jialiang, Liu
Xinmei, Yang
The role of EGFR-TKI for leptomeningeal metastases from non-small cell lung cancer
title The role of EGFR-TKI for leptomeningeal metastases from non-small cell lung cancer
title_full The role of EGFR-TKI for leptomeningeal metastases from non-small cell lung cancer
title_fullStr The role of EGFR-TKI for leptomeningeal metastases from non-small cell lung cancer
title_full_unstemmed The role of EGFR-TKI for leptomeningeal metastases from non-small cell lung cancer
title_short The role of EGFR-TKI for leptomeningeal metastases from non-small cell lung cancer
title_sort role of egfr-tki for leptomeningeal metastases from non-small cell lung cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972805/
https://www.ncbi.nlm.nih.gov/pubmed/27536527
http://dx.doi.org/10.1186/s40064-016-2873-2
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