Cargando…

Promoter-Specific Hypomethylation Correlates with IL-1β Overexpression in Tuberous Sclerosis Complex (TSC)

In tuberous sclerosis complex (TSC), overexpression of numerous genes associated with inflammation has been observed. Among different proinflammatory cytokines, interleukin-1β (IL-1β) has been shown to be significantly involved in epileptogenesis and maintenance of seizures. Recent evidence indicate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fuso, A., Iyer, A. M., van Scheppingen, J., Maccarrone, M., Scholl, T., Hainfellner, J. A., Feucht, M., Jansen, F. E., Spliet, W. G., Krsek, P., Zamecnik, J., Mühlebner, A., Aronica, E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972849/ https://www.ncbi.nlm.nih.gov/pubmed/27122151 http://dx.doi.org/10.1007/s12031-016-0750-7

Ejemplares similares

Myelin Pathology Beyond White Matter in Tuberous Sclerosis Complex (TSC) Cortical Tubers
por: Mühlebner, Angelika, et al.
Publicado: (2020)

Specific pattern of maturation and differentiation in the formation of cortical tubers in tuberous sclerosis omplex (TSC): evidence from layer-specific marker expression
por: Mühlebner, Angelika, et al.
Publicado: (2016)

Novel Histopathological Patterns in Cortical Tubers of Epilepsy Surgery Patients with Tuberous Sclerosis Complex
por: Mühlebner, Angelika, et al.
Publicado: (2016)

Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment
por: Mills, James D., et al.
Publicado: (2017)

Author Correction: Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment
por: Mills, James D., et al.
Publicado: (2022)

Subependymal giant cell astrocytomas in Tuberous Sclerosis Complex have consistent TSC1/TSC2 biallelic inactivation, and no BRAF mutations
por: Bongaarts, Anika, et al.
Publicado: (2017)

Dysregulation of the (immuno)proteasome pathway in malformations of cortical development
por: van Scheppingen, J., et al.
Publicado: (2016)

Down-regulation of the brain-specific cell-adhesion molecule contactin-3 in tuberous sclerosis complex during the early postnatal period
por: Korotkov, Anatoly, et al.
Publicado: (2022)

MicroRNA‐34a activation in tuberous sclerosis complex during early brain development may lead to impaired corticogenesis
por: Korotkov, Anatoly, et al.
Publicado: (2021)

Increased expression of complement components in tuberous sclerosis complex and focal cortical dysplasia type 2B brain lesions
por: Gruber, Victoria‐Elisabeth, et al.
Publicado: (2021)

Impaired oligodendroglial turnover is associated with myelin pathology in focal cortical dysplasia and tuberous sclerosis complex
por: Scholl, Theresa, et al.
Publicado: (2017)

Dysregulation of the MMP/TIMP Proteolytic System in Subependymal Giant Cell Astrocytomas in Patients With Tuberous Sclerosis Complex: Modulation of MMP by MicroRNA-320d In Vitro
por: Bongaarts, Anika, et al.
Publicado: (2020)

Distinct DNA Methylation Patterns of Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex
por: Bongaarts, Anika, et al.
Publicado: (2021)

Molecular EPISTOP, a comprehensive multi-omic analysis of blood from Tuberous Sclerosis Complex infants age birth to two years
por: Huschner, Franz, et al.
Publicado: (2023)

The coding and non-coding transcriptional landscape of subependymal giant cell astrocytomas
por: Bongaarts, Anika, et al.
Publicado: (2020)

Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex
por: Li, Yi, et al.
Publicado: (2018)

Increased matrix metalloproteinases expression in tuberous sclerosis complex: modulation by microRNA 146a and 147b in vitro
por: Broekaart, D. W. M., et al.
Publicado: (2019)

Efficacy and safety of Everolimus in children with TSC - associated epilepsy – Pilot data from an open single-center prospective study
por: Samueli, Sharon, et al.
Publicado: (2016)

The Neurodevelopmental Pathogenesis of Tuberous Sclerosis Complex (TSC)
por: Feliciano, David M.
Publicado: (2020)

Understanding the impact of tuberous sclerosis complex: development and validation of the TSC-PROM
por: Müller, Annelieke R., et al.
Publicado: (2023)

Moderate lifelong overexpression of tuberous sclerosis complex 1 (TSC1) improves health and survival in mice
por: Zhang, Hong-Mei, et al.
Publicado: (2017)

Prevention of Epilepsy in Infants with Tuberous Sclerosis Complex in the EPISTOP Trial
por: Kotulska, Katarzyna, et al.
Publicado: (2020)

Mutational analysis of TSC1 and TSC2 genes in Tuberous Sclerosis Complex patients from Greece
por: Avgeris, Socratis, et al.
Publicado: (2017)

Tuberous Sclerosis Complex (TSC): Expert Recommendations for Provision of Coordinated Care
por: Annear, Nicholas M. P., et al.
Publicado: (2019)

Correction: Understanding the impact of tuberous sclerosis complex: development and validation of the TSC-PROM
por: Müller, Annelieke R., et al.
Publicado: (2023)

Differential expression and clinical significance of three inflammation-related microRNAs in gangliogliomas
por: Prabowo, A. S., et al.
Publicado: (2015)

Mutational analysis of TSC1 and TSC2 in Danish patients with tuberous sclerosis complex
por: Rosengren, Thomas, et al.
Publicado: (2020)

Is autism driven by epilepsy in infants with Tuberous Sclerosis Complex?
por: Moavero, Romina, et al.
Publicado: (2020)

Molecular rescue of Tsc1-ablated cortical tuber mice
por: Robens, Barbara, et al.
Publicado: (2016)

TSC1 and TSC2 Genotype in Tuberous Sclerosis Complex: Are Other Manifestations of this Multisystem Disease Affected by Genotype?
por: Darling, Thomas N., et al.
Publicado: (2021)

Tuberous Sclerosis Complex as Disease Model for Investigating mTOR-Related Gliopathy During Epileptogenesis
por: Zimmer, Till S., et al.
Publicado: (2020)

Nipple angiofibromas with loss of TSC2 are associated with tuberous sclerosis complex
por: Nathan, Neera, et al.
Publicado: (2015)

Molecular analysis of TSC1 and TSC2 genes and phenotypic correlations in Brazilian families with tuberous sclerosis
por: Rosset, Clévia, et al.
Publicado: (2017)

TSC1 and TSC2 gene mutations and their implications for treatment in Tuberous Sclerosis Complex: a review
por: Rosset, Clévia, et al.
Publicado: (2017)

tsc2 mutant zebrafish model of tuberous sclerosis complex
Publicado: (2011)

TSC1 Mutations in Keratoconus Patients With or Without Tuberous Sclerosis
por: Bykhovskaya, Yelena, et al.
Publicado: (2017)

Upregulation of the pathogenic transcription factor SPI1/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress
por: Zimmer, Till S., et al.
Publicado: (2021)

First comprehensive TSC1/TSC2 mutational analysis in Mexican patients with Tuberous Sclerosis Complex reveals numerous novel pathogenic variants
por: Reyna-Fabián, Miriam E., et al.
Publicado: (2020)

PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential therapeutic target for Tuberous Sclerosis Complex
por: Alves, Maria M., et al.
Publicado: (2015)

Functional characterisation of the TSC1–TSC2 complex to assess multiple TSC2 variants identified in single families affected by tuberous sclerosis complex
por: Nellist, Mark, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_0d9ers85siotokkc7tf3p39kp3