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Corneal Biomechanics Determination in Healthy Myopic Subjects
Purpose. To determine the corneal biomechanical properties by using the Ocular Response Analyzer™ and to investigate potential factors associated with the corneal biomechanics in healthy myopic subjects. Methods. 135 eyes from 135 healthy myopic subjects were included in this cross-sectional observa...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972914/ https://www.ncbi.nlm.nih.gov/pubmed/27525109 http://dx.doi.org/10.1155/2016/2793516 |
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author | Qiu, Kunliang Lu, Xuehui Zhang, Riping Wang, Geng Zhang, Mingzhi |
author_facet | Qiu, Kunliang Lu, Xuehui Zhang, Riping Wang, Geng Zhang, Mingzhi |
author_sort | Qiu, Kunliang |
collection | PubMed |
description | Purpose. To determine the corneal biomechanical properties by using the Ocular Response Analyzer™ and to investigate potential factors associated with the corneal biomechanics in healthy myopic subjects. Methods. 135 eyes from 135 healthy myopic subjects were included in this cross-sectional observational study. Cornea hysteresis (CH), corneal resistance factor (CRF), cornea-compensated intraocular pressure (IOPcc), and Goldmann-correlated intraocular pressure (IOPg) were determined with the Reichert Ocular Response Analyzer (ORA). Univariate and multivariate regression analyses were performed to investigate factors associated with corneal biomechanics. Results. The mean CH and CRF were 9.82 ± 1.34 mmHg and 9.64 ± 1.57 mmHg, respectively. In univariate regression analysis, CH was significantly correlated with axial length, refraction, central corneal thickness (CCT), and IOPg (r = −0.27, 0.23, 0.45, and 0.21, resp.; all with p ≤ 0.015), but not with corneal curvature or age; CRF was significantly correlated with CCT and IOPg (r = 0.52 and 0.70, resp.; all with p < 0.001), but not with axial length/refraction, corneal curvature, or age. In multivariate regression analysis, axial length, IOPcc, and CCT were found to be independently associated with CH, while CCT and IOPg were associated with CRF. Conclusions. Both CH and CRF were positively correlated with CCT. Lower CH but not CRF was associated with increasing degree of myopia. Evaluation of corneal biomechanical properties should take CCT and myopic status into consideration. |
format | Online Article Text |
id | pubmed-4972914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-49729142016-08-14 Corneal Biomechanics Determination in Healthy Myopic Subjects Qiu, Kunliang Lu, Xuehui Zhang, Riping Wang, Geng Zhang, Mingzhi J Ophthalmol Research Article Purpose. To determine the corneal biomechanical properties by using the Ocular Response Analyzer™ and to investigate potential factors associated with the corneal biomechanics in healthy myopic subjects. Methods. 135 eyes from 135 healthy myopic subjects were included in this cross-sectional observational study. Cornea hysteresis (CH), corneal resistance factor (CRF), cornea-compensated intraocular pressure (IOPcc), and Goldmann-correlated intraocular pressure (IOPg) were determined with the Reichert Ocular Response Analyzer (ORA). Univariate and multivariate regression analyses were performed to investigate factors associated with corneal biomechanics. Results. The mean CH and CRF were 9.82 ± 1.34 mmHg and 9.64 ± 1.57 mmHg, respectively. In univariate regression analysis, CH was significantly correlated with axial length, refraction, central corneal thickness (CCT), and IOPg (r = −0.27, 0.23, 0.45, and 0.21, resp.; all with p ≤ 0.015), but not with corneal curvature or age; CRF was significantly correlated with CCT and IOPg (r = 0.52 and 0.70, resp.; all with p < 0.001), but not with axial length/refraction, corneal curvature, or age. In multivariate regression analysis, axial length, IOPcc, and CCT were found to be independently associated with CH, while CCT and IOPg were associated with CRF. Conclusions. Both CH and CRF were positively correlated with CCT. Lower CH but not CRF was associated with increasing degree of myopia. Evaluation of corneal biomechanical properties should take CCT and myopic status into consideration. Hindawi Publishing Corporation 2016 2016-07-21 /pmc/articles/PMC4972914/ /pubmed/27525109 http://dx.doi.org/10.1155/2016/2793516 Text en Copyright © 2016 Kunliang Qiu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Qiu, Kunliang Lu, Xuehui Zhang, Riping Wang, Geng Zhang, Mingzhi Corneal Biomechanics Determination in Healthy Myopic Subjects |
title | Corneal Biomechanics Determination in Healthy Myopic Subjects |
title_full | Corneal Biomechanics Determination in Healthy Myopic Subjects |
title_fullStr | Corneal Biomechanics Determination in Healthy Myopic Subjects |
title_full_unstemmed | Corneal Biomechanics Determination in Healthy Myopic Subjects |
title_short | Corneal Biomechanics Determination in Healthy Myopic Subjects |
title_sort | corneal biomechanics determination in healthy myopic subjects |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972914/ https://www.ncbi.nlm.nih.gov/pubmed/27525109 http://dx.doi.org/10.1155/2016/2793516 |
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