Marked changes in dendritic structure and spine density precede significant neuronal death in vulnerable cortical pyramidal neuron populations in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is characterised by the death of upper (corticospinal) and lower motor neurons (MNs) with progressive muscle weakness. This incurable disease is clinically heterogeneous and its aetiology remains unknown. Increased excitability of corticospinal MNs has been observ...

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Detalles Bibliográficos
Autores principales: Fogarty, Matthew J., Mu, Erica W. H., Noakes, Peter G., Lavidis, Nickolas A., Bellingham, Mark C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973034/
https://www.ncbi.nlm.nih.gov/pubmed/27488828
http://dx.doi.org/10.1186/s40478-016-0347-y

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