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The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact

Zika virus (ZIKV) is a mosquito-borne flavivirus that has newly emerged as a significant global threat, especially to pregnancy. Recent major outbreaks in the Pacific and in Central and South America have been associated with an increased incidence of microcephaly and other abnormalities of the cent...

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Autores principales: Boeuf, Phillipe, Drummer, Heidi E., Richards, Jack S., Scoullar, Michelle J. L., Beeson, James G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973112/
https://www.ncbi.nlm.nih.gov/pubmed/27487767
http://dx.doi.org/10.1186/s12916-016-0660-0
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author Boeuf, Phillipe
Drummer, Heidi E.
Richards, Jack S.
Scoullar, Michelle J. L.
Beeson, James G.
author_facet Boeuf, Phillipe
Drummer, Heidi E.
Richards, Jack S.
Scoullar, Michelle J. L.
Beeson, James G.
author_sort Boeuf, Phillipe
collection PubMed
description Zika virus (ZIKV) is a mosquito-borne flavivirus that has newly emerged as a significant global threat, especially to pregnancy. Recent major outbreaks in the Pacific and in Central and South America have been associated with an increased incidence of microcephaly and other abnormalities of the central nervous system in neonates. The causal link between ZIKV infection during pregnancy and microcephaly is now strongly supported. Over 2 billion people live in regions conducive to ZIKV transmission, with ~4 million infections in the Americas predicted for 2016. Given the scale of the current pandemic and the serious and long-term consequences of infection during pregnancy, the impact of ZIKV on health services and affected communities could be enormous. This further highlights the need for a rapid global public health and research response to ZIKV to limit and prevent its impact through the development of therapeutics, vaccines, and improved diagnostics. Here we review the epidemiology of ZIKV; the threat to pregnancy; the clinical consequences and broader impact of ZIKV infections; and the virus biology underpinning new interventions, diagnostics, and insights into the mechanisms of disease.
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spelling pubmed-49731122016-08-05 The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact Boeuf, Phillipe Drummer, Heidi E. Richards, Jack S. Scoullar, Michelle J. L. Beeson, James G. BMC Med Review Zika virus (ZIKV) is a mosquito-borne flavivirus that has newly emerged as a significant global threat, especially to pregnancy. Recent major outbreaks in the Pacific and in Central and South America have been associated with an increased incidence of microcephaly and other abnormalities of the central nervous system in neonates. The causal link between ZIKV infection during pregnancy and microcephaly is now strongly supported. Over 2 billion people live in regions conducive to ZIKV transmission, with ~4 million infections in the Americas predicted for 2016. Given the scale of the current pandemic and the serious and long-term consequences of infection during pregnancy, the impact of ZIKV on health services and affected communities could be enormous. This further highlights the need for a rapid global public health and research response to ZIKV to limit and prevent its impact through the development of therapeutics, vaccines, and improved diagnostics. Here we review the epidemiology of ZIKV; the threat to pregnancy; the clinical consequences and broader impact of ZIKV infections; and the virus biology underpinning new interventions, diagnostics, and insights into the mechanisms of disease. BioMed Central 2016-08-03 /pmc/articles/PMC4973112/ /pubmed/27487767 http://dx.doi.org/10.1186/s12916-016-0660-0 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Boeuf, Phillipe
Drummer, Heidi E.
Richards, Jack S.
Scoullar, Michelle J. L.
Beeson, James G.
The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact
title The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact
title_full The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact
title_fullStr The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact
title_full_unstemmed The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact
title_short The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact
title_sort global threat of zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973112/
https://www.ncbi.nlm.nih.gov/pubmed/27487767
http://dx.doi.org/10.1186/s12916-016-0660-0
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